Monday, June 23, 2025

5G Wireless Technology: Millimeter Wave Health Effects

The emergence of 5G, fifth-generation telecommunications technology, has been in the news lately because the wireless industry has been pushing controversial legislation at the state and federal level to expedite the deployment of this technology. The legislation would block the rights of local governments and their citizens to control the installation of cellular antennas in the public “right-of-way.” Cell antennas may be installed on public utility poles every 10-20 houses in urban areas. According to the industry, as many as 50,000 new cell sites will be required in California and 800,000 or more new cell sites nationwide.

Although many major cities and newspapers have opposed this legislation, the potential health risks from the proliferation of new cellular antenna sites have been ignored. These cell antennas will expose the population to new sources of radio frequency radiation including millimeter waves in addition to microwaves.

5G will employ low- (0.6 GHz - 3.7 GHz), mid- (3.7 – 24 GHz), and high-band frequencies (24 GHz and higher). In the U.S., the Federal Communications Commission (FCC) has allocated “low-band” spectrum at 0.6 GHz (e.g., 600 MHz), “mid-band” spectrum in the 3.5 GHz range, and 11 GHz of “high-band” frequencies including licensed spectrum from 27.5-28.35 GHz and 37-40 GHz, as well as unlicensed spectrum from 64-71 GHz which is open to all wireless equipment manufacturers.



Prior to widespread deployment, major cell phone carriers are experimenting with new technologies that employ “high-band” frequencies in communities across the country. The “high-band” frequencies largely consist of millimeter waves (MMWs), a type of electromagnetic radiation with wavelengths of one to ten millimeters and frequencies ranging from 30 to 300 GHz (or billions of cycles per second). 

The characteristics of MMWs are different than the “low-band” (i.e., microwave) frequencies which are currently in use by the cellular and wireless industries. MMWs can transmit large amounts of data over short distances. The transmissions can be directed into narrow beams that travel by line-of-sight and can move data at high rates (e.g., up to 10 billion bits per second) with short lags (or latencies) between transmissions. The signals are blocked by buildings, and foliage can absorb much of their energy. Also, the waves can be reflected by metallic surfaces. Although antennas can be as small as a few millimeters, “small cell” antenna arrays may consist of dozens or even hundreds of antenna elements.

What does research tell us about the biologic and health effects of millimeter waves?

Millimeter waves (MMWs) are mostly absorbed within 1 to 2 millimeters of human skin and in the surface layers of the cornea. Thus, the skin or near-surface zones of tissues are the primary targets of the radiation. Since skin contains capillaries and nerve endings, MMW bio-effects may be transmitted through molecular mechanisms by the skin or through the nervous system. 

Thermal (or heating) effects occur when the power density of the waves is above 5–10 mW/cm2. Such high-intensity MMWs act on human skin and the cornea in a dose-dependent manner—beginning with heat sensation followed by pain and physical damage at higher exposures. Temperature elevation can impact the growth, morphology and metabolism of cells, induce production of free radicals, and damage DNA.

The maximum permissible exposure that the FCC permits for the general public is 1.0 mW/cm2 averaged over 30 minutes for frequencies that range from 1.5 GHz to 100 GHz. This guideline was adopted in 1996 to protect humans from acute exposure to thermal levels of radiofrequency radiation. However, the guidelines were not designed to protect us from nonthermal risks that may occur with prolonged or long-term exposure to radiofrequency radiation.

With the deployment of fifth generation wireless infrastructure (aka 5G), much of the nation will be exposed to MMWs for the first time on a continuous basis. Due to FCC guidelines, these exposures will likely be of low intensity. Hence, the health consequences of 5G exposure will be limited to non-thermal effects produced by prolonged exposure to MMWs in conjunction with exposure to low- and mid-band radiofrequency radiation.

Unfortunately, few studies have examined prolonged exposure to low-intensity MMWs, and no research that I am aware of has focused on exposure to MMWs combined with other radiofrequency radiation.

Although biologic effects of low-intensity MMWs have been studied for decades, particularly in Eastern Europe, study results are often inconsistent because the effects are related to many factors including the frequency, modulation, power density, and duration of the exposures, as well as the type of tissue or cells being investigated.

Results vary across studies—MMWs have been shown to induce or inhibit cell death and enhance or suppress cell proliferation. Some studies found that the radiation inhibits cell cycle progression, and some studies reported no biologic effects (Le Drean et al., 2013)

A review of the research in 2010 noted that “A large number of cellular studies have indicated that MMW may alter structural and functional properties of membranes.” Exposure to MMWs may affect the plasma membrane either by modifying ion channel activity or by modifying the phospholipid bilayer. Water molecules also seem to play a role in these effects. Skin nerve endings are a likely target of MMWs and the possible starting point of numerous biological effects. MMWs may activate the immune system through stimulation of the peripheral neural system (Ramundo-Orlando, 2010).

In 1998, five scientists employed by U.S. Army and Air Force research institutes published a seminal review of the research on MMWs. They reported:

“Increased sensitivity and even hypersensitivity of individual specimens to MMW may be real. Depending on the exposure characteristics, especially wavelength, a low-intensity MMW radiation was perceived by 30 to 80% of healthy examinees (Lebedeva, 1993, 1995). Some clinical studies reported MMW hypersensitivity, which was or was not limited to a certain wavelength (Golovacheva, 1995).”

“It is important to note that, even with the variety of bioeffects reported, no studies have provided evidence that a low-intensity MMW radiation represents a health hazard for human beings. Actually, none of the reviewed studies with low-intensity MMW even pursued the evaluation of health risks, although in view of numerous bioeffects and growing usage of MMW technologies this research objective seems very reasonable. Such MMW effects as alterations of cell growth rate and UV light sensitivity, biochemical and antibiotic resistivity changes in pathogenic bacteria, as well as many others are of potential significance for safety standards, but even local and short-term exposures were reported to produce marked effects. It should also be realized that biological effects of a prolonged or chronic MMW exposure of the whole body or a large body area have never been investigated. Safety limits for these types of exposures are based solely on predictions of energy deposition and MMW heating, but in view of recent studies this approach is not necessarily adequate.” (Pakhomov et al., 1998)

Microbes are also affected by MMW radiation. In 2016 a review of the research on the effects of MMWs on bacteria was published (Soghomonyan et al., 2016). The authors summarized their findings as follows:

“…bacteria and other cells might communicate with each other by electromagnetic field of sub-extremely high frequency range. These MMW affected Escherichia coli and many other bacteria, mainly depressing their growth and changing properties and activity. These effects were non-thermal and depended on different factors. The significant cellular targets for MMW effects could be water, cell plasma membrane, and genome….The consequences of MMW interaction with bacteria are the changes in their sensitivity to different biologically active chemicals, including antibiotics….These effects are of significance for understanding changed metabolic pathways and distinguish role of bacteria in environment; they might be leading to antibiotic resistance in bacteria.”

Changing the sensitivity of bacteria to antibiotics by MMW irradiation can be important for the understanding of antibiotic resistance in the environment. In this respect, it is interesting that bacteria [that] survived near telecommunication-based stations like Bacillus and Clostridium spp. have been found to be multidrug resistant (Adebayo et al. 2014).”  (Soghomonyan et al., 2016)

In sum, the peer-reviewed research demonstrates that short-term exposure to low-intensity millimeter wave (MMW) radiation not only affects human cells, it may result in the growth of multi-drug resistant bacteria harmful to humans. Since little research has been conducted on the health consequences from long-term exposure to MMWs, widespread deployment of 5G or 5th generation wireless infrastructure constitutes a massive experiment that may have adverse impacts on the public’s health.

Early Russian research on millimeter radiation

Russian scientists conducted much of the early research on the effects of exposure to millimeter radiation. The U.S.Central Intelligence Agency collected and translated the published research but did not declassify it until decades later. 

In 1977, N.P. Zalyubovskaya published a study, "Biological effects of millimeter waves," in a Russian-language journal, "Vracheboyne Delo." The CIA declassified this paper in 2012. 

The study examined the effects of exposing mice to millimeter radiation (37-60 GHz; 1 milliwatt per square centimeter) for 15 minutes daily for 60 days. The animal results were compared to a sample of people working with millimeter generators.

Here is a brief summary of the paper:



   Excerpts:



The paper can be downloaded from http://bit.ly/MMWstudy1977.

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References to many MMW biologic studies can be found in EMF-Portal (as of 6/23/2025).

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Following are summaries of research reviews of the effects of MMW exposure and a list of recently published studies.

Millimeter Wave Research Reviews

(Updated August 15, 2023)

Dagli N, Dagli R; Thangavelu L. Interaction of Millimetre Waves Used in 5G Network with Cells and Tissues of Head-and-Neck Region: A Literature Review. Advances in Human Biology 13(2):p 168-176, Apr–Jun 2023. | DOI: 10.4103/aihb.aihb_133_22 .

Abstract

Fifth-generation mobile technology is supposed to revolutionise the world. It has many features which can benefit humankind, but at the same time, it will expose us to much radiation. Therefore, we need to understand the importance and ill effects of 5 G technology. An online literature search was conducted through PubMed and Scopus databases from April 2021 to May 2021, using the Boolean operators OR, AND and NOT and the keywords ‘5G Network’, ‘Human tissues’, and ‘Animal tissues’. The literature is very scarce in studies on the effects of millimetre waves on various tissues. A total of 1269 studies were identified, and 24 were selected for qualitative evidence synthesis. Randomised control trials, laboratory studies, in-vitro studies, in-vivo studies and ex-vivo studies were included. Data from the studies were collected using the data extraction form, and all the relevant information was summarized. Five of 24 studies were done on animals, four on humans, five on models, and ten on various cells. Ten of 24 studies demonstrated the harmful effects of millimetre waves. Results are ambivalent, and no association is found between particular frequency and impact on tissue, animals or humans. Pathophysiological effects observed in most studies were mild, reversible, and limited to the cellular level. Available evidence reported temperature rise after millimetre wave exposure, which was within safety limits. Any biological impact on a cellular level noticed due to radiation’s thermal effects were insignificant and did not affect the organ level. However, only a few studies have mentioned non-thermal impact, but those effects should not be overlooked. Clinical trials on a large population and for a longer duration are required to establish the safety of millimetre waves before deploying a 5G network worldwide.

Conclusion

Very few studies published related to the effects of millimetre waves on various tissues. Therefore, it is very difficult to reach a clear conclusion. Available evidence suggests that heating effects in tissues due to MMW exposure cause temperature rise. However, the temperature rise was found to be within safety limits for the short duration of exposure, but biological effects on the cellular level were observed in a few studies. It is unclear how these changes will affect organs or individuals when the population is exposed to radiation continuously for a lifetime. Very few studies have shown harmful non-thermal effects too. These effects should not be overlooked. Special attention should be paid to the tissues of the head and neck region as they are in close proximity to electromagnetic devices. More research is required to confirm those findings and the chronic thermal and non-thermal effects of MMW and to establish safety before the deployment of 5G networks all over the world. Technological advancement is necessary for human race development but not at the cost of our health. We need to limit the use of certain frequencies at workplaces where a high amount of data is required to be transferred at high speed and find the safest frequency for widespread use so that our environment and the next generations can be protected from hazardous effects.

Future study recommendation

Very few studies have been done on the effects of millimetre waves on humans. Clinical trials on a large population and for longer duration are required to establish the safety of millimetre waves before the 5G network roll out all over the world. The effect of other environmental toxic stimuli should be considered while studying the effect of MMW. Other factors that affect the absorption of MMW, such as the shadowing effect, reflection from surrounding tissues, angle of a screen of a device, thickness of skin and the water content of the skin should be considered.


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Martin L Pall. Millimeter (MM) wave and microwave frequency radiation produce deeply penetrating effects: the biology and the physics. Rev Environ Health. 2021 May 26. doi: 10.1515/reveh-2020-0165.

 
Abstract

Millimeter wave (MM-wave) electromagnetic fields (EMFs) are predicted to not produce penetrating effects in the body. The electric but not magnetic part of MM-EMFs are almost completely absorbed within the outer 1 mm of the body. Rodents are reported to have penetrating MM-wave impacts on the brain, the myocardium, liver, kidney and bone marrow. MM-waves produce electromagnetic sensitivity-like changes in rodent, frog and skate tissues. In humans, MM-waves have penetrating effects including impacts on the brain, producing EEG changes and other neurological/neuropsychiatric changes, increases in apparent electromagnetic hypersensitivity and produce changes on ulcers and cardiac activity. This review focuses on several issues required to understand penetrating effects of MM-waves and microwaves: 1. Electronically generated EMFs are coherent, producing much higher electrical and magnetic forces then do natural incoherent EMFs. 2. The fixed relationship between electrical and magnetic fields found in EMFs in a vacuum or highly permeable medium such as air, predicted by Maxwell's equations, breaks down in other materials. Specifically, MM-wave electrical fields are almost completely absorbed in the outer 1 mm of the body due to the high dielectric constant of biological aqueous phases. However, the magnetic fields are very highly penetrating. 3. Time-varying magnetic fields have central roles in producing highly penetrating effects. The primary mechanism of EMF action is voltage-gated calcium channel (VGCC) activation with the EMFs acting via their forces on the voltage sensor, rather than by depolarization of the plasma membrane. Two distinct mechanisms, an indirect and a direct mechanism, are consistent with and predicted by the physics, to explain penetrating MM-wave VGCC activation via the voltage sensor. Time-varying coherent magnetic fields, as predicted by the Maxwell-Faraday version of Faraday's law of induction, can put forces on ions dissolved in aqueous phases deep within the body, regenerating coherent electric fields which activate the VGCC voltage sensor. In addition, time-varying magnetic fields can directly put forces on the 20 charges in the VGCC voltage sensor. There are three very important findings here which are rarely recognized in the EMF scientific literature: coherence of electronically generated EMFs; the key role of time-varying magnetic fields in generating highly penetrating effects; the key role of both modulating and pure EMF pulses in greatly increasing very short term high level time-variation of magnetic and electric fields. It is probable that genuine safety guidelines must keep nanosecond timescale-variation of coherent electric and magnetic fields below some maximum level in order to produce genuine safety. These findings have important implications with regard to 5G radiation.

https://pubmed.ncbi.nlm.nih.gov/34043892/

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Dariusz Leszczynski. Physiological effects of millimeter-waves on skin and skin cells: an overview of the to-date published studies. Reviews on Environmental Health. DOI: https://doi.org/10.1515/reveh-2020-0056. Published online: 24 Aug 2020. 

Abstract

The currently ongoing deployment of the fifth generation of the wireless communication technology, 5G technology, has reignited the health debate around the new kind of radiation that will be used/emitted by 5G devices and networks – the millimeter-waves. The new aspect of 5G technology, that is of concern to some of the future users, is that both, antennas and devices will be continuously in a very close proximity of the users’ bodies. Skin is the only organ of the human body, besides the eyes, that will be directly exposed to the mm-waves of 5G technology. However, the whole scientific evidence on the possible effects of millimeter-waves on skin and skin cells, currently consists of only some 99 studies. This clearly indicates that the scientific evidence concerning the possible effects of millimeter-waves on humans is insufficient to devise science-based exposure limits and to develop science-based human health policies. The sufficient research has not been done and, therefore, precautionary measures should be considered for the deployment of 5G, before the sufficient number of quality research studies will be executed and health risk, or lack of it, scientifically established.

Excerpt

Therefore, the recently published guidelines by the International Commission on Non-Ionizing Radiation Protection (ICNIRP) [103], stating that the ICNIRP proposed mm-waves radiation exposure limits are protecting users form health effects of mm-waves are only an assumption that is not sufficiently based on scientific evidence because the research on effects of mm-waves on skin has not been performed. This is why any claims, including ICNIRP’s, that the current safety limits protect all users, no matter of their age or their health status, have no sufficient scientific basis. The safety limits that are suggested to protect from health effects of mm-waves are based on scientifically unsupported assumptions as seen from the evidence presented in Tables 1– 4.


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Alekseev SI, Ziskin MC. Biological effects of millimeter and submillimeter waves. Handbook of Biological Effects of Electromagnetic Fields (B. Greenebaum and F. Barnes, editors), 4th ed., Chapter 6, pp. 179-242, 2019, CRC Press, Boca Raton, FL.


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Belyaev IY, Shcheglov VS, Alipov ED, Ushakov VD. Nonthermal effects of extremely high-frequency microwaves on chromatin conformation in cells in vitro—Dependence on physical, physiological, and genetic factors. IEEE Transactions on Microwave Theory and Techniques. 2000; 48(11):2172-2179.

Abstract

There is a substantial number of studies showing biological effects of microwaves of extremely high-frequency range [i.e., millimeter waves (MMWs)] at nonthermal intensities, but poor reproducibility was reported in few replication studies. One possible explanation could be the dependence of the MMW effects on some parameters, which were not controlled in replications. The authors studied MMW effects on chromatin conformation in Escherichia coli (E. coli) cells and rat thymocytes. Strong dependence of MMW effects on frequency and polarization was observed at nonthermal power densities. Several other factors were important, such as the genotype of a strain under study, growth stage of the bacterial cultures, and time between exposure to microwaves and recording of the effect. MMW effects were dependent on cell density during exposure. This finding suggested an interaction of microwaves with cell-to-cell communication. Such dependence on several genetic, physiological, and physical variables might be a reason why, in some studies, the authors failed to reproduce the original data of others.


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Le Drean Y, Mahamoud YS, Le Page Y, Habauzit D, Le Quement C, Zhadobov M, Sauleau R. State of knowledge on biological effects at 40–60 GHz. Comptes Rendus Physique. 2013; 14(5):402-411.

Abstract

Millimetre waves correspond to the range of frequencies located between 30 and 300 GHz. Many applications exist and are emerging in this band, including wireless telecommunications, imaging and monitoring systems. In addition, some of these frequencies are used in therapy in Eastern Europe, suggesting that interactions with the human body are possible. This review aims to summarise current knowledge on interactions between millimetre waves and living matter. Several representative examples from the scientific literature are presented. Then, possible mechanisms of interactions between millimetre waves and biological systems are discussed.


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Pakhomov AG, Akyel Y, Pakhomova ON, Stuck BE, Murphy MR. Current state and implications of research on biological effects of millimeter waves: a review of the literature. Bioelectromagnetics. 1998; 19(7):393-413.

In recent years, research into biological and medical effects of millimeter waves (MMW) has expanded greatly. This paper analyzes general trends in the area and briefly reviews the most significant publications, proceeding from cell-free systems, dosimetry, and spectroscopy issues through cultured cells and isolated organs to animals and humans. The studies reviewed demonstrate effects of low-intensity MMW (10 mW/cm2 and less) on cell growth and proliferation, activity of enzymes, state of cell genetic apparatus, function of excitable membranes, peripheral receptors, and other biological systems. In animals and humans, local MMW exposure stimulated tissue repair and regeneration, alleviated stress reactions, and facilitated recovery in a wide range of diseases (MMW therapy). Many reported MMW effects could not be readily explained by temperature changes during irradiation. The paper outlines some problems and uncertainties in the MMW research area, identifies tasks for future studies, and discusses possible implications for development of exposure safety criteria and guidelines.


Ramundo-Orlando A. Effects of millimeter waves radiation on cell membrane - A brief review. Journal of Infrared, Millimeter, and Terahertz Waves.  2010; 31(12):1400–1411.

Abstract

The millimeter waves (MMW) region of the electromagnetic spectrum, extending from 30 to 300 GHz in terms of frequency (corresponding to wavelengths from 10 mm to 1 mm), is officially used in non-invasive complementary medicine in many Eastern European countries against a variety of diseases such gastro duodenal ulcers, cardiovascular disorders, traumatism and tumor. On the other hand, besides technological applications in traffic and military systems, in the near future MMW will also find applications in high resolution and high-speed wireless communication technology. This has led to restoring interest in research on MMW induced biological effects. In this review emphasis has been given to the MMW-induced effects on cell membranes that are considered the major target for the interaction between MMW and biological systems.


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Ryan KL, D'Andrea JA, Jauchem JR, Mason PA. Radio frequency radiation of millimeter wave length: potential occupational safety issues relating to surface heating.  Health Phys. 2000; 78(2):170-81.

Abstract

Currently, technology is being developed that makes use of the millimeter wave (MMW) range (30-300 GHz) of the radio frequency region of the electromagnetic spectrum. As more and more systems come on line and are used in everyday applications, the possibility of inadvertent exposure of personnel to MMWs increases. To date, there has been no published discussion regarding the health effects of MMWs; this review attempts to fill that void. Because of the shallow depth of penetration, the energy and, therefore, heat associated with MMWs will be deposited within the first 1-2 mm of human skin. MMWs have been used in states of the former Soviet Union to provide therapeutic benefit in a number of diverse disease states, including skin disorders, gastric ulcers, heart disease and cancer. Conversely, the possibility exists that hazards might be associated with accidental overexposure to MMWs. This review attempts to critically analyze the likelihood of such acute effects as burn and eye damage, as well as potential long-term effects, including cancer.


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Soghomonyan D, Trchounian K, Trchounian A. Millimeter waves or extremely high frequency electromagnetic fields in the environment: what are their effects on bacteria? Appl Microbiol Biotechnol. 2016; 100(11):4761-71. doi: 10.1007/s00253-016-7538-0.

Abstract

Millimeter waves (MMW) or electromagnetic fields of extremely high frequencies at low intensity is a new environmental factor, the level of which is increased as technology advance. It is of interest that bacteria and other cells might communicate with each other by electromagnetic field of sub-extremely high frequency range. These MMW affected Escherichia coli and many other bacteria, mainly depressing their growth and changing properties and activity. These effects were non-thermal and depended on different factors. The significant cellular targets for MMW effects could be water, cell plasma membrane, and genome. The model for the MMW interaction with bacteria is suggested; a role of the membrane-associated proton FOF1-ATPase, key enzyme of bioenergetic relevance, is proposed. The consequences of MMW interaction with bacteria are the changes in their sensitivity to different biologically active chemicals, including antibiotics. Novel data on MMW effects on bacteria and their sensitivity to different antibiotics are presented and discussed; the combined action of MMW and antibiotics resulted with more strong effects. These effects are of significance for understanding changed metabolic pathways and distinguish role of bacteria in environment; they might be leading to antibiotic resistance in bacteria. The effects might have applications in the development of technique, therapeutic practices, and food protection technology.


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Torgomyan H, Trchounian A. Bactericidal effects of low-intensity extremely high frequency electromagnetic field: an overview with phenomenon, mechanisms, targets and consequences. Crit Rev Microbiol. 2013; 39(1):102-11.

Abstract

Low-intensity electromagnetic field (EMF) of extremely high frequencies is a widespread environmental factor. This field is used in telecommunication systems, therapeutic practices and food protection. Particularly, in medicine and food industries EMF is used for its bactericidal effects. The significant targets of cellular mechanisms for EMF effects at resonant frequencies in bacteria could be water (H2O), cell membrane and genome. The changes in H2O cluster structure and properties might be leading to increase of chemical activity or hydration of proteins and other cellular structures. These effects are likely to be specific and long-term. Moreover, cell membrane with its surface characteristics, substance transport and energy-conversing processes is also altered. Then, the genome is affected because the conformational changes in DNA and the transition of bacterial pro-phages from lysogenic to lytic state have been detected. The consequences for EMF interaction with bacteria are the changes in their sensitivity to different chemicals, including antibiotics. These effects are important to understand distinguishing role of bacteria in environment, leading to changed metabolic pathways in bacteria and their antibiotic resistance. This EMF may also affect the cell-to-cell interactions in bacterial populations, since bacteria might interact with each other through EMF of sub-extremely high frequency range.


Betskii OV Devyatkov ND, Kislov VV. Low intensity millimeter waves in medicine and biology. Crit Rev Biomed Eng. 2000;28(1-2):247-68. 

Abstract

This paper provides evidence on the interaction of objects. Basic regularities of that interaction are discussed.

Conclusions 

Summarizing the results of the 30-year study of biological effects of low-intensity MM waves, we may ascertain the following. As it often happens, applied research and commercialization have outdistanced fundamental investigations. The wide application of MM waves in medicine, biotechnology, animal husbandry, and plant cultivation has taken a giant step forward. By this time, Russia has manufactured more than 10,000 MM-wave therapy devices, organized more than 2,500 MM-wave therapy rooms, and treated over 2,500,000 patients....

https://www.ncbi.nlm.nih.gov/pubmed/10999395 

Open access version of paper: https://pdfs.semanticscholar.org/d0f5/d75d92b7fb8f4d13ae5461e26afa62e87e60.pdf

See also: 

May EC, Faith LV. The effects of electromagnetic radiation on biological systems: Current status in the former Soviet Union. Science Applications International Corporation. Presented to US Government, Feb 26, 1993. Approved for release by US Central Intelligence Agency, Aug 10, 2000. https://www.cia.gov/library/readingroom/docs/CIA-RDP96-00792R000100070001-9.pdf 

Recent Millimeter Wave Studies
(Last Update: July 13, 2022)

Banday Y, Rather GM, Begh Gh R. Effect of atmospheric absorption on millimetre wave frequencies for 5G cellular networks. IET Commun. 2019. 13(3):265-270. https://doi.org/10.1049/iet-com.2018.5044

Bantysh BB, Krylov AY, Subbotina TI, et al. Peculiar effects of electromagnetic millimeter waves on tumor development in BALB/c mice. Bull Exp Biol Med. 2018 Sep;165(5):692-694. https://www.ncbi.nlm.nih.gov/pubmed/30225701

Christ A, Samaras T, Neufeld E, Kuster N. RF-induced temperature increase in a stratified model of the skin for plane-wave exposure at 6-100 GHz. Radiat Prot Dosimetry. 2020 Jan 16. pii: ncz293. doi: 10.1093/rpd/ncz293. https://www.ncbi.nlm.nih.gov/pubmed/31950182 

Dilli R. Implications of mmWave radiation on human health: State of the art threshold levels. IEEE Access. 18 January 2021. doi:  10.1109/ACCESS.2021.3052387.  https://ieeexplore.ieee.org/document/9328127

Foster KR, Ziskin MC, Balzano Q. Thermal response of human skin to microwave energy: A critical review. Health Phys. 2016; 111(6):528-541. (Note: This work was sponsored by the Mobile Manufacturers Forum. The authors state that MMF had no control over the contents.)  https://www.ncbi.nlm.nih.gov/pubmed/27798477

Gajda GB, Lemay E, Paradis J. Model of Steady-state Temperature Rise in Multilayer Tissues Due to Narrow-beam Millimeter-wave Radiofrequency Field Exposure. Health Phys. 2019 Feb 15. doi: 10.1097/HP.0000000000001036.  https://insights.ovid.com/pubmed?pmid=31125321

Gandhi OP, Riazi A. Absorption of millimeter waves by human beings and its biological implications. IEEE Transactions on Microwave Theory and Techniques. MTT-34(2):228-235. 1986. http://bit.ly/2oS3rKD

Haas AJ, Le Page Y, Zhadobov M, et al. Effects of 60-GHz millimeter waves on neurite outgrowth in PC12 cells using high-content screening. Neurosci Lett. 2016 Apr 8;618:58-65.
https://www.ncbi.nlm.nih.gov/pubmed/26921450

Haas AJ, Le Page Y, Zhadobov M, et al. Effect of acute millimeter wave exposure on dopamine metabolism of NGF-treated PC12 cells. J Radiat Res. 2017 Feb 24:1-7. https://www.ncbi.nlm.nih.gov/pubmed/28339776

He W, Xu B, Yao Y, Colombi D, Ying Z, He S. Implications of incident power density limits on power and EIRP Levels of 5G millimeter-wave user equipment. IEEE Access. 10 Aug 2020. Open access paper: https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=9163106

Héliot F, Loh TH, Cheadle D, Gui Y, Dieudonne M. An Empirical Study of the Stochastic Nature of Electromagnetic Field Exposure in Massive MIMO Systems. IEEE Access, vol. 10, pp. 63100-63112, 2022, doi:  10.1109/ACCESS.2022.3182236. https://ieeexplore.ieee.org/document/9794655

Hovnanyan K, Kalantaryan V, Trchounian A. The distinguishing effects of low intensity electromagnetic radiation of different extremely high frequences on Enterococcus hirae: growth rate inhibition and scanning electron microscopy analysis. Lett Appl Microbiol. 2017. https://www.ncbi.nlm.nih.gov/pubmed/28609553

Kojima M, Tsai C-Y, Suzuki Y, et al. Ocular response to millimeter wave exposure under different humidity levels. J Infrared Millimeter Terahertz Waves. 40(5):474-484. 2019.  https://link.springer.com/article/10.1007/s10762-019-00586-0

Koyama S, Narita E, Shimizu Y, et al. Effects of long-term exposure to 60 GHz millimeter-wavelength radiation on the genotoxicity and heat shock protein (Hsp) expression of cells derived from human eye. Int J Environ Res Public Health. 2016 Aug 8;13(8). pii: E802. https://www.ncbi.nlm.nih.gov/pubmed/27509516

Lemay E, Gajda GB, McGarr GW, et al. Analysis of ICNIRP 2020 Basic Restrictions for Localized Radiofrequency Exposure in the Frequency Range Above 6 GHz. Health Phys. 2022 May 21. doi: 10.1097/HP.0000000000001581. https://journals.lww.com/health-physics/Fulltext/9900/Analysis_of_ICNIRP_2020_Basic_Restrictions_for.15.aspx

Le Pogam P, Le Page Y, Habauzit D, et al. Untargeted metabolomics unveil alterations of biomembranes permeability in human HaCaT keratinocytes upon 60 GHz millimeter-wave exposure. Sci Rep. 2019 Jun 27;9(1):9343. doi: 10.1038/s41598-019-45662-6. Open access paper: https://www.nature.com/articles/s41598-019-45662-6

Li Y, Lu M. Study on SAR distribution of electromagnetic exposure of 5G mobile antenna in human brain. J. Appl. Sci. Eng. 23, 279–287 (2020). Open access paper: http://jase.tku.edu.tw/articles/jase-202006-23-2-0012

Parker JE, Beason CW, Sturgeon SP, Voorhees WB, Johnson SS, et al. Revisiting 35 and 94 GHZ Millimeter Wave Exposure to the Non-human Primate Eye. Health Phys. 2020 Jun 3. doi: 10.1097/HP.0000000000001216. https://pubmed.ncbi.nlm.nih.gov/32501817/https://pubmed.ncbi.nlm.nih.gov/32501817/

Romanenko S, Harvey AR, Hool L, Fan S, Wallace VP. Millimeter wave radiation activates leech nociceptors via TRPV1-like receptor sensitization. Biophys J. 2019 Apr 25. pii: S0006-3495(19)30340-6. doi: 10.1016/j.bpj.2019.04.021.  https://www.ncbi.nlm.nih.gov/pubmed/31103236 

Sivachenko IB, Medvedev DS, Molodtsova ID, et al. Effects of millimeter-wave electromagnetic radiation on the experimental model of migraine. Bull Exp Biol Med. 2016 Feb;160(4):425-8. doi: 10.1007/s10517-016-3187-7. http://www.ncbi.nlm.nih.gov/pubmed/26899844

Wang Q, Zhao X, Li S, et al. Attenuation by a human body and trees as well as material penetration loss in 26 and 39 GHz millimeter wave bands. International Journal of Antennas and Propagation. 2017. https://doi.org/10.1155/2017/2961090.

Wu T, Rappaport TS, Collins CM. The human body and millimeter-wave wireless communication systems: Interactions and implications. IEEE International Conference on Communications (ICC), Jun 2015. https://ieeexplore.ieee.org/document/7248688

Friday, June 20, 2025

Research on Smart Phone and Internet Addiction

Smart Phone/Cellphone Dependence/Addiction


​ Addictive Screen Use Trajectories and Suicidal Behaviors, Suicidal Ideation, and Mental Health in US Youths

​Xiao Y, Meng Y, Brown TT, Keyes KM, Mann JJ. Addictive Screen Use Trajectories and Suicidal Behaviors, Suicidal Ideation, and Mental Health in US Youths. JAMA. Published online June 18, 2025. doi:10.1001/jama.2025.7829

Key Points

Question  Are addictive screen use trajectories associated with suicidal behaviors, suicidal ideation, and mental health outcomes in US youth?

Findings  In this cohort study of 4285 US adolescents, 31.3% had increasing addictive use trajectories for social media and 24.6% for mobile phones over 4 years. High or increasing addictive use trajectories were associated with elevated risks of suicidal behaviors or ideation compared with low addictive use. Youths with high-peaking or increasing social media use or high video game use had more internalizing or externalizing symptoms.

Meaning  Both high and increasing addictive screen use trajectories were associated with suicidal behaviors, suicidal ideation, and worse mental health in youths.

Abstract

Importance  Increasing child and adolescent use of social media, video games, and mobile phones has raised concerns about potential links to youth mental health problems. Prior research has largely focused on total screen time rather than longitudinal addictive use trajectories.

Objectives  To identify trajectories of addictive use of social media, mobile phones, and video games and to examine their associations with suicidal behaviors and ideation and mental health outcomes among youths.

Design, Setting, and Participants  Cohort study analyzing data from baseline through year 4 follow-up in the Adolescent Brain Cognitive Development Study (2016-2022), with population-based samples from 21 US sites.

Exposures  Addictive use of social media, mobile phones, and video games using validated child-reported measures from year 2, year 3, and year 4 follow-up surveys.

Main Outcomes and Measures  Suicidal behaviors and ideation assessed using child- and parent-reported information via the Kiddie Schedule for Affective Disorders and Schizophrenia. Internalizing and externalizing symptoms were assessed using the parent-reported Child Behavior Checklist.

Results  The analytic sample (n = 4285) had a mean age of 10.0 (SD, 0.6) years; 47.9% were female; and 9.9% were Black, 19.4% Hispanic, and 58.7% White. Latent class linear mixed models identified 3 addictive use trajectories for social media and mobile phones and 2 for video games. Nearly one-third of participants had an increasing addictive use trajectory for social media or mobile phones beginning at age 11 years. In adjusted models, increasing addictive use trajectories were associated with higher risks of suicide-related outcomes than low addictive use trajectories (eg, increasing addictive use of social media had a risk ratio of 2.14 [95% CI, 1.61-2.85] for suicidal behaviors). High addictive use trajectories for all screen types were associated with suicide-related outcomes (eg, high-peaking addictive use of social media had a risk ratio of 2.39 [95% CI, 1.66-3.43] for suicidal behaviors). The high video game addictive use trajectory showed the largest relative difference in internalizing symptoms (T score difference, 2.03 [95% CI, 1.45-2.61]), and the increasing social media addictive use trajectory for externalizing symptoms (T score difference, 1.05 [95% CI, 0.54-1.56]), compared with low addictive use trajectories. Total screen time at baseline was not associated with outcomes.

Conclusions and Relevance  High or increasing trajectories of addictive use of social media, mobile phones, or video games were common in early adolescents. Both high and increasing addictive screen use trajectories were associated with suicidal behaviors and ideation and worse mental health.



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Sound of silence: Does muting notifications reduce phone use?

Mengqi Liao, S. Shyam Sundar. Sound of silence: Does muting notifications reduce phone use? Computers in Human Behavior. Volume 134, 2022, 107338. doi:10.1016/j.chb.2022.107338.

Highlights

• Silencing mobile phones (no sound or vibrations) predicts more mobile phone use and phone-checking behaviors in general.
• Users with high FoMO will use their mobile phone significantly more when it is in silent mode.
• Users with higher NtB will use their mobile phone significantly more when it is muted.

Abstract

Smartphone users often feel disturbed by the constant rings and buzzes coming from their phones. As a solution, many try to silence notifications to avoid distractions. But, will silencing notifications help users feel less distracted or more preoccupied with what they will be missing out? To answer this question, we drew upon the Uses & Gratifications (U&G) approach in the field of communication and conducted a study of objective behavioral data collected from the Screen Time tool of 138 iPhone users. Data suggest that users tend to pick up their phones and check for messages more often when it is in silent mode than when it is on audio-alert or vibrate modes. This tendency is especially true for individuals who have high Fear of Missing Out (FoMO) and Need to Belong (NtB). Silencing notifications for them appears to be more, rather than less, psychologically distressing. Our findings offer new insights into understanding the relationship between notifications and mobile phone usage, especially how the sound and vibration cues of notifications assuage users’ uncertainty and fulfil their informational, social and environmental surveillance gratifications. Results also suggest that many current solutions for mobile phone overuse, like the “Do not disturb” function, may be counter-productive.



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Gangadharan N, Borle A L, Basu S (April 04, 2022) Mobile Phone Addiction as an Emerging Behavioral Form of Addiction Among Adolescents in India. Cureus 14(4): e23798. doi:10.7759/cureus.23798

Abstract

Introduction: The advancements in mobile phones from simple basic phones to featured phones and smartphones resulted in the penetration of technology to different groups of people irrespective of age, gender, or region. Thus, mobile phone addiction has evolved as a form of behavioral addiction found to be increasingly prevalent among adolescents too. The study aimed to determine the prevalence of mobile phone addiction among adolescents and its associated risk factors among adolescents.

Method and results: A community-based, cross-sectional study was conducted among 264 adolescents (10-19 years) of low-income urban areas of Delhi. The prevalence of mobile phone addiction in the participants was 33.0% (95% CI: 27.2-38.6). The addiction was higher among boys (33.6%) than girls (32.3%) (p=0.835). Mobile phone addiction was found to be significantly higher among those adolescents who had ≥3 siblings, those belonging to nuclear families, and among late-onset users (≥16 years). Late-onset users (adjusted odds ratio {aOR}: 3.398; 95% CI: 1.307-8.833) and ≥3 siblings (aOR: 1.980; 95% CI: 1.141-3.437) were independent predictors of mobile phone addiction. The mean time spent on mobile phones was significantly higher among those with addiction but no significant gender difference was found between time spent on phones and addiction.

Conclusion: The high prevalence of mobile phone addiction found in our study is an indication of the potential public health concern posed by mobile phone use among adolescents in urban settings. Hence, it is essential to limit the access to mobile phones for important utility purposes for adolescents.

Open access paper: https://www.cureus.com/articles/78761-mobile-phone-addiction-as-an-emerging-behavioral-form-of-addiction-among-adolescents-in-india 

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Ying Li, Guangxiao Li, Li Liu, Hui Wu. Correlations between mobile phone addiction and anxiety, depression, impulsivity, and poor sleep quality among college students: A systematic review and meta-analysis. J Behav Addict. 2020 Sep 8. doi: 10.1556/2006.2020.00057.

Abstract

Background and aims: Mobile phone addiction (MPA) is frequently reported to be correlated with anxiety, depression, stress, impulsivity, and sleep quality among college students. However, to date, there is no consensus on the extent to which those factors are correlated with MPA among college students. We thus performed a meta-analysis to quantitatively synthesize the previous findings.

Methods: A systematic review and meta-analysis was conducted by searching PubMed, Embase, Cochrane Library, Wanfang, Chinese National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database (VIP), and Chinese Biological Medicine (CBM) databases from inception to August 1, 2020. Pooled Pearson's correlation coefficients between MPA and anxiety, depression, impulsivity, and sleep quality were calculated by R software using random effects model.

Results: Forty studies involving a total of 33,650 college students were identified. Weak-to-moderate positive correlations were found between MPA and anxiety, depression, impulsivity and sleep quality (anxiety: summary r = 0.39, 95% CI = 0.34-0.45, P < 0.001, I2 = 84.9%; depression: summary r = 0.36, 95% CI = 0.32-0.40, P < 0.001, I2 = 84.2%; impulsivity: summary r = 0.38, 95% CI = 0.28-0.47, P < 0.001, I2 = 94.7%; sleep quality: summary r = 0.28, 95% CI = 0.22-0.33, P < 0.001, I2 = 85.6%). The pooled correlations revealed some discrepancies when stratified by some moderators. The robustness of our findings was further confirmed by sensitivity analyses.

Conclusions: The current meta-analysis provided solid evidence that MPA was positively correlated with anxiety, depression, impulsivity, and sleep quality. This indicated that college students with MPA were more likely to develop high levels of anxiety, depression, and impulsivity and suffer from poor sleep quality. More studies, especially large prospective studies, are warranted to verify our findings.


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O'Donnell S, Epstein LH. Smartphones are more reinforcing than food for students. Addict Behav. 2018 Oct 18;90:124-133. doi: 10.1016/j.addbeh.2018.10.018. 

Highlights

• College students engage in high frequency smartphone use despite consequences.

• Comparing smartphones to food may establish their relative reinforcing value.
• Students were deprived of food and smartphones before working for both reinforcers.
• Phones were more reinforcing than food, and smartphone reinforcement was related to smartphone use.
• Smartphones are potent reinforcers, which may be why people use smartphones excessively.

Abstract

College students engage in high-frequency smartphone use, despite potential negative consequences. One way to conceptualize this behavior is to consider it a highly reinforcing activity. Comparing motivation for smartphones to a powerful primary reinforcer, such as food, can establish their relative reinforcing value. This study investigated whether smartphones were more reinforcing than food, as well as the relationships between smartphone reinforcement, texting use, and smartphone motives. Participants were 76 college students (50% female, Mage = 18.9, SD = 0.99) who had no access to food for three hours and to their smartphones for two hours. After this modest deprivation period, participants worked for time to use their smartphones and 100-cal portions of their favorite snack food concurrently, with the work to obtain portions of both commodities increasing. The amount of smartphone use earned during the task was manipulated across groups (20, 30, 60, 120 s) to establish what amount of smartphone use was needed to motivate responding. Additionally, reinforcing efficacy of smartphones and food using a hypothetical purchase task and motivations for smartphone use was collected. Smartphones were more reinforcing than food using either measurement methodology (p's < 0.001). Smartphone reinforcement predicted number of text messages, controlling for age, sex, and family income. Positive smartphone use motives were associated with reinforcing efficacy of smartphones. These data show that smartphones are potent reinforcers, and are more reinforcing than food given modest food deprivation. These methods provide one important reason why people may use smartphones.

Excerpt

College students share a perception that smartphone ownership is beneficial; however smartphone use has been linked to increased anxiety (Jenaro, Flores, Gómez-Vela, González-Gil, & Caballo, 2007), social dysfunction (Jenaro et al., 2007) insomnia (Jenaro et al., 2007), low self-esteem (Bianchi & Phillips, 2005; Smetaniuk, 2014), emotional instability (Roberts, Pullig, & Manolis, 2015; Smetaniuk, 2014) and depression (Ezoe et al., 2009; Smetaniuk, 2014). Temporarily removing cell phones from high frequency cell phone users increased self-reported anxiety over a 75 min time period in comparison to less frequent users (Cheever et al., 2014). Despite the negative outcomes associated with problematic smartphone use, college students are highly motivated to use their smartphones.

https://www.ncbi.nlm.nih.gov/pubmed/30390436

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Kates AW, Wu H, Chris LSC. The effects of mobile phone use on academic performance: A meta-analysis. Computers & Education. 127:107-112. Dec 2018. https://doi.org/10.1016/j.compedu.2018.08.012

Highlights

• Study purpose is to further examine any relationships that may exist between mobile phone use and educational achievement.
• A meta-analysis on the relationship between mobile phone use & academic outcomes over 10 years (2008–2017) was conducted.
• Results indicate the summary effect of mobile phone use on student outcomes is r = −0.16 with 95% CI of −0.20 to −0.13.

Abstract

Purpose  Although the mobile phone has been conspicuously proliferated in the past decades, little is known about its influence; especially its effect on student learning and academic performance. Although there is a growing interest in mobile devices and their correlates and consequences for children, effects vary across related studies and the magnitude of the overall effect remains unclear. The purpose of this study is to further examine any relationships that may exist between mobile phone use and educational achievement.

Research design  A meta-analysis of research conducted on the relationship between mobile phone use and student educational outcomes over a 10-year period (2008–2017) was conducted. The operational definition of cell phone use to guide the implementation of this study is: any measure of mobile phone use, whether considered normative or problematic, that quantifies the extent to which a person uses a phone, feels an emotional or other dependence on a phone, or categorizes the types of uses and situations in which use occurs. Studies examining use for the express purpose of educational improvement are not included, as the aim of this study is to ascertain the effects of normal smartphone use. The operational definition of academic achievement to guide the implementation of this study is: any measure that quantifies the extent to which a student or group of students is performing or feels he or she is performing to a satisfactory level, including but not limited to letter grades and test scores, knowledge and skill acquisition, and self-reported measures of academic ability or difficulty.

Findings  The overall meta-analysis indicated that the average effect of mobile phone usage on student outcomes was r =  −0.162 with a 95% confident interval of −0.196 to −0.128. The effect sizes of moderator variables (education level, region, study type, and whether the effect size was derived from a Beta coefficient, and mobile phone use construct) were analyzed. The results of this study and their implications for both research and practice are discussed.

Excerpts

The results of this study indicate that, overall, mobile phone use has a small negative effect (r = −0.16) on educational outcomes which is consistent with the previous literature (Lepp et al., 2015; Li et al., 2015). However, the results caution against coming to hasty conclusions based on these findings. The summary effect size is relatively small, even in the educational sphere. Hattie (2012), for example, conducted over 900 educational meta-analyses and found the largest summary effect for a classroom intervention to be a Cohen's d of 1.44. Taking this into account, it is not surprising that something so ubiquitous and increasingly integral to students' lives would have some influence on educational outcomes. Additionally, although the publication bias analysis suggests that these results are not greatly biased by a systematic exclusion of studies, it should be noted that the effects observed could be indicative of an association rather than causation. For example, those who are predisposed to overuse mobile devices may simply be less likely to achieve academically in the first place. That the summary effect is derived from studies involving experimental groups as well as cross-sectional studies, however, brings this possibility into question....


Despite the variability between studies, there appears to be a consistent negative, albeit small, effect on educational achievement. This suggests that avoidance of mobile phones in educational settings, or for those who are currently in school, could be beneficial for academic achievement..... 


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Kuss DJ, Kanjo E, Crook-Rumsey M, Kibowski F, Wang GY, Sumich A. Problematic mobile phone use and addiction across generations: the roles of psychopathological symptoms and smartphone use. J Technol Behav Sci. 2018;3(3):141-149. doi: 10.1007/s41347-017-0041-3.

Abstract

Contemporary technological advances have led to a significant increase in using mobile technologies. Recent research has pointed to potential problems as a consequence of mobile overuse, including addiction, financial problems, dangerous use (i.e. whilst driving) and prohibited use (i.e. use in forbidden areas). The aim of this study is to extend previous findings regarding the predictive power of psychopathological symptoms (depression, anxiety and stress), mobile phone use (i.e. calls, SMS, time spent on the phone, as well as the engagement in specific smartphone activities) across Generations X and Y on problematic mobile phone use in a sample of 273 adults. Findings revealed prohibited use and dependence were predicted by calls/day, time on the phone and using social media. Only for dependent mobile phone use (rather than prohibited), stress appeared as significant. Using social media and anxiety significantly predicted belonging to Generation Y, with calls per day predicted belonging to Generation X. This finding suggests Generation Y are more likely to use asynchronous social media-based communication, whereas Generation X engage more in synchronous communication. The findings have implications for prevention and awareness-raising efforts of possibly problematic mobile phone use for educators, parents and individuals, particularly including dependence and prohibited use.


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Kim J-H. Psychological issues and problematic use of smartphone: ADHD's moderating role in the associations among loneliness, need for social assurance, need for immediate connection, and problematic use of smartphone. Computers in Human Behavior. 80:390-398. Mar 2018. https://doi.org/10.1016/j.chb.2017.11.025

Highlights

• Examined the mechanism linking loneliness with problematic use of smartphone.
• ADHD increased levels of loneliness, NSA, NIC, and problematic use of smartphone.
• FtF interaction decreased the association between NSA and NIC for those with ADHD.

Abstract

Going beyond looking at the direct association between psychological issues (loneliness and ADHD) and problematic use of media (smartphone), the present study examined the covert mechanism connecting the two. NSA (need for social assurance) and NIC (need for immediate connection) were selected as mediating steps between the two. A total of 615 U.S. American participants were recruited nationally for survey participation. Research findings suggest that individuals who are lonely would rely on smartphone hoping to be connected with and get assurance from others, but might end up struggling with problematic use of smartphone. Those with ADHD showed higher levels of loneliness, NSA, NIC, and problematic use of smartphone, and also showed stronger associations linking loneliness, NSA and NIC compared to those without ADHD. Face-to-face (FtF) interaction decreased the association between NSA and NIC for those with ADHD.


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Carbonell X, Chamarro A, Oberst U, Rodrigo B, Prades M. Problematic Use of the Internet and Smartphones in University Students: 2006-2017. Intl J Environ Research Publ Health. 15(3). Article 475. Mar 2018.

Abstract

It has been more than a decade since a concern about the addictive use of the Internet and mobile phones was first expressed, and its possible inclusion into the lists of mental disorders has recently become a popular topic of scientific discussion. Thus, it seems to be a fitting moment to investigate the prevalence of this issue over time. The aim of the present study was to analyze the prevalence of the perception of problematic Internet and smartphone use in young people over the period 2006-2017. To this end, a questionnaire on Internet use habits and two questionnaires on the negative consequences of Internet and smartphone use were administered to a sample of 792 university students. The scores were then compared with the results of former studies that had used these questionnaires. The perception of problematic Internet and mobile phone use has increased over the last decade, social networks are considered responsible for this increase, and females are perceived to be more affected than males. The current study shows how strong smartphone and Internet addiction and social media overlap. Participants from 2017 report higher negative consequences of both Internet and mobile phone use than those from 2006, but long-term observations show a decrease in problematic use after a sharp increase in 2013. We conclude that the diagnosis of technological addictions is influenced by both time and social and culture changes.


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Zou Z, Wang H, d'Oleire Uquillas F, Wang X, Ding J, Chen H. Definition of Substance and Non-substance Addiction. Adv Exp Med Biol. 2017;1010:21-41.

Abstract

Substance addiction (or drug addiction) is a neuropsychiatric disorder characterized by a recurring desire to continue taking the drug despite harmful consequences. Non-substance addiction (or behavioral addiction) covers pathological gambling, food addiction, internet addiction, and mobile phone addiction. Their definition is similar to drug addiction but they differ from each other in specific domains. This review aims to provide a brief overview of past and current definitions of substance and non-substance addiction, and also touches on the topic of diagnosing drug addiction and non-drug addiction, ultimately aiming to further the understanding of the key concepts needed for a foundation to study the biological and psychological underpinnings of addiction disorders.


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Gao T, Xiang YT, Zhang H, Zhang Z, Mei S. Neuroticism and quality of life: Multiple mediating effects of smartphone addiction and depression. Psychiatry Res. 2017 Dec;258:457-461. doi: 10.1016/j.psychres.2017.08.074.

Abstract

The purposes of this study were to investigate the mediating effect of smartphone addiction and depression on neuroticism and quality of life. Self-reported measures of neuroticism, smart-phone addiction, depression, and quality of life were administered to 722 Chinese university students. Results showed smartphone addiction and depression were both significantly affected neuroticism and quality of life. The direct effect of neuroticism on quality of life was significant, and the chain-mediating effect of smartphone addiction and depression was also significant. In conclusion, neuroticism, smartphone addiction, and depression are important variables that worsen quality of life.


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Kim HJ, Min JY, Kim HJ, Min KB. Accident risk associated with smartphone addiction: A study on university students in Korea. J Behav Addict. 2017 Nov 3:1-9. doi: 10.1556/2006.6.2017.070.

Abstract

Background and aims: The smartphone is one of the most popular devices, with the average smartphone usage at 162 min/day and the average length of phone usage at 15.79 hr/week. Although significant concerns have been made about the health effects of smartphone addiction, the relationship between smartphone addiction and accidents has rarely been studied. We examined the association between smartphone addiction and accidents among South Korean university students.

Methods: A total of 608 college students completed an online survey that included their experience of accidents (total number; traffic accidents; falls/slips; bumps/collisions; being trapped in the subway, impalement, cuts, and exit wounds; and burns or electric shocks), their use of smartphone, the type of smartphone content they most frequently used, and other variables of interests. Smartphone addiction was estimated using Smartphone Addiction Proneness Scale, a standardized measure developed by the National Institution in Korea.

Results: Compared with normal users, participants who were addicted to smartphones were more likely to have experienced any accidents (OR = 1.90, 95% CI: 1.26-2.86), falling from height/slipping (OR = 2.08, 95% CI: 1.10-3.91), and bumps/collisions (OR = 1.83, 95% CI: 1.16-2.87). The proportion of participants who used their smartphones mainly for entertainment was significantly high in both the accident (38.76%) and smartphone addiction (36.40%) groups.

Discussion and conclusions: We suggest that smartphone addiction was significantly associated with total accident, falling/slipping, and bumps/collisions. This finding highlighted the need for increased awareness of the risk of accidents with smartphone addiction.


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Wolniewicz CA, Tiamiyu MF, Weeks JW, Elhai JD. Problematic smartphone use and relations with negative affect, fear of missing out, and fear of negative and positive evaluation. Psychiatry Res. 2017 Sep 25. pii: S0165-1781(17)30901-0. doi: 10.1016/j.psychres.2017.09.058.

Abstract

For many individuals, excessive smartphone use interferes with everyday life. In the present study, we recruited a non-clinical sample of 296 participants for a cross-sectional survey of problematic smartphone use, social and non-social smartphone use, and psychopathology-related constructs including negative affect, fear of negative and positive evaluation, and fear of missing out (FoMO). Results demonstrated that FoMO was most strongly related to both problematic smartphone use and social smartphone use relative to negative affect and fears of negative and positive evaluation, and these relations held when controlling for age and gender. Furthermore, FoMO (cross-sectionally) mediated relations between both fear of negative and positive evaluation with both problematic and social smartphone use. Theoretical implications are considered with regard to developing problematic smartphone use.


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Han S, Kim KJ, Kim JH. Understanding Nomophobia: Structural Equation Modeling and Semantic Network Analysis of Smartphone Separation Anxiety. Cyberpsychol Behav Soc Netw. 2017 Jul;20(7):419-427. doi: 10.1089/cyber.2017.0113.

Abstract

This study explicates nomophobia by developing a research model that identifies several determinants of smartphone separation anxiety and by conducting semantic network analyses on smartphone users' verbal descriptions of the meaning of their smartphones. Structural equation modeling of the proposed model indicates that personal memories evoked by smartphones encourage users to extend their identity onto their devices. When users perceive smartphones as their extended selves, they are more likely to get attached to the devices, which, in turn, leads to nomophobia by heightening the phone proximity-seeking tendency. This finding is also supplemented by the results of the semantic network analyses revealing that the words related to memory, self, and proximity-seeking are indeed more frequently used in the high, compared with low, nomophobia group.


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Lee H, Kim JW, Choi TY. Risk Factors for Smartphone Addiction in Korean Adolescents: Smartphone Use Patterns. J Korean Med Sci. 2017 Oct;32(10):1674-1679. doi: 10.3346/jkms.2017.32.10.1674.

Abstract

With widespread use of the smartphone, clinical evidence for smartphone addiction remains unclear. Against this background, we analyzed the effect of smartphone use patterns on smartphone addiction in Korean adolescents. A total of 370 middle school students participated. The severity of smartphone addiction was measured through clinical interviews and the Korean Smartphone Addiction Proneness Scale. As a result, 50 (13.5%) were in the smartphone addiction group and 320 (86.5%) were in the healthy group. To investigate the effect of smartphone use patterns on smartphone addiction, we performed self-report questionnaires that assessed the following items: smartphone functions mostly used, purpose of use, problematic use, and parental attitude regarding smartphone use. For smartphone functions mostly used, the addiction group showed significantly higher scores in "Online chat." For the purpose of use, the addiction group showed significantly higher "habitual use," "pleasure," "communication," "games," "stress relief," "ubiquitous trait," and "not to be left out." For problematic use, the addiction group showed significantly higher scores on "preoccupation," "tolerance," "lack of control," "withdrawal," "mood modification," "conflict," "lies," "excessive use," and "loss of interest." For parental attitude regarding children's smartphone use, the addiction group showed significantly higher scores in "parental punishment." Binary logistic regression analysis indicated that "female," "use for learning," "use for ubiquitous trait," "preoccupation," and "conflict" were significantly correlated with smartphone addiction. This study demonstrated that the risk factors for smartphone addiction were being female, preoccupation, conflict, and use for ubiquitous trait; the protective factor was use for learning. Future studies will be required to reveal the additional clinical evidence of the disease entity for smartphone addiction.
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Kuss DJ, Griffiths MD. Social Networking Sites and Addiction: Ten Lessons Learned. Int J Environ Res Public Health. 2017 Mar 17;14(3). pii: E311. doi: 10.3390/ijerph14030311.
Abstract
Online social networking sites (SNSs) have gained increasing popularity in the last decade, with individuals engaging in SNSs to connect with others who share similar interests. The perceived need to be online may result in compulsive use of SNSs, which in extreme cases may result in symptoms and consequences traditionally associated with substance-related addictions. In order to present new insights into online social networking and addiction, in this paper, 10 lessons learned concerning online social networking sites and addiction based on the insights derived from recent empirical research will be presented. These are: (i) social networking and social media use are not the same; (ii) social networking is eclectic; (iii) social networking is a way of being; (iv) individuals can become addicted to using social networking sites; (v) Facebook addiction is only one example of SNS addiction; (vi) fear of missing out (FOMO) may be part of SNS addiction; (vii) smartphone addiction may be part of SNS addiction; (viii) nomophobia may be part of SNS addiction; (ix) there are sociodemographic differences in SNS addiction; and (x) there are methodological problems with research to date. These are discussed in turn. Recommendations for research and clinical applications are provided.

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De-Sola Gutiérrez J, Rodríguez de Fonseca F, Rubio G. Cell-Phone Addiction: A Review. Front Psychiatry. 2016 Oct 24;7:175.

Abstract

We present a review of the studies that have been published about addiction to cell phones. We analyze the concept of cell-phone addiction as well as its prevalence, study methodologies, psychological features, and associated psychiatric comorbidities. Research in this field has generally evolved from a global view of the cell phone as a device to its analysis via applications and contents. The diversity of criteria and methodological approaches that have been used is notable, as is a certain lack of conceptual delimitation that has resulted in a broad spread of prevalent data. There is a consensus about the existence of cell-phone addiction, but the delimitation and criteria used by various researchers vary. Cell-phone addiction shows a distinct user profile that differentiates it from Internet addiction. Without evidence pointing to the influence of cultural level and socioeconomic status, the pattern of abuse is greatest among young people, primarily females. Intercultural and geographical differences have not been sufficiently studied. The problematic use of cell phones has been associated with personality variables, such as extraversion, neuroticism, self-esteem, impulsivity, self-identity, and self-image. Similarly, sleep disturbance, anxiety, stress, and, to a lesser extent, depression, which are also associated with Internet abuse, have been associated with problematic cell-phone use. In addition, the present review reveals the coexistence relationship between problematic cell-phone use and substance use such as tobacco and alcohol.

https://www.ncbi.nlm.nih.gov/pubmed/27822187

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Bragazzi NL, Del Puente G. A proposal for including nomophobia in the new DSM-V. Psychol Res Behav Manag. 2014 May 16;7:155-60. doi: 10.2147/PRBM.S41386.

Abstract

The Diagnostic and Statistical Manual of Mental Disorders (DSM) is considered to be the gold standard manual for assessing the psychiatric diseases and is currently in its fourth version (DSM-IV), while a fifth (DSM-V) has just been released in May 2013. The DSM-V Anxiety Work Group has put forward recommendations to modify the criteria for diagnosing specific phobias. In this manuscript, we propose to consider the inclusion of nomophobia in the DSM-V, and we make a comprehensive overview of the existing literature, discussing the clinical relevance of this pathology, its epidemiological features, the available psychometric scales, and the proposed treatment. Even though nomophobia has not been included in the DSM-V, much more attention is paid to the psychopathological effects of the new media, and the interest in this topic will increase in the near future, together with the attention and caution not to hypercodify as pathological normal behaviors.

Open source paper: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036142/

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Hussain Z. Smartphone Use, Addiction, Narcissism, and Personality: A Mixed Methods Investigation.International Journal of Cyber Behavior, Psychology and Learning. 5(1):17-32. 2015.

Abstract

There are increasing numbers of people who are now using smartphones. Consequently, there is a risk of addiction to certain web applications such as social networking sites (SNSs) which are easily accessible via smartphones. There is also the risk of an increase in narcissism amongst users of SNSs. 
The present study set out to investigate the relationship between smartphone use, narcissistic tendencies and personality as predictors of smartphone addiction. The study also aimed to investigate the distinction between addiction specificity and co-occurrence in smartphone addiction via qualitative data and discover why people continue to use smartphones in banned areas. A self-selected sample of 256 smartphone users (Mean age = 29.2, SD = 9.49) completed an online survey. The results revealed that 13.3% of the sample was classified as addicted to smartphones. Higher narcissism scores and neuroticism levels were linked to addiction. Three themes of; social relations, smartphone dependence and self-serving personalities emerged from the qualitative data. Interpretation of qualitative data supports addiction specificity of the smartphone. It is suggested smartphones encourage narcissism, even in non-narcissistic users. In turn, this increased use in banned areas. Future research needs to gather more in-depth qualitative data, addiction scale comparisons and comparison of use with and without SNS access. It is advised that prospective buyers of smartphones be pre-warned of the potential addictive properties of new technology.

Internet Addiction

Sussman CJ, Harper JM, Stahl JL, Weigel P. Internet and Video Game Addictions: Diagnosis, Epidemiology, and Neurobiology. Child Adolesc Psychiatric Clin N Am 27 (2018) 307–326. https://doi.org/10.1016/j.chc.2017.11.015.

Key Points

  • Proposed criteria for diagnosis of Internet gaming disorder and other digital technology addictions are analogous to those for substance use or gambling disorders.
  • Diagnosis of Internet and video game addictions should include both screening tools and clinical interview for “red flags,” such as academic decline, sleep disruption, and changes in real-life activities and relationships.
  • Epidemiologic studies, limited by variation in diagnostic methods, yield prevalence estimates ranging from less than 1.0% to 26.8%.
  • Internet and video game addictions are associated with psychological and social comorbidities, such as depression, attention-deficit/hyperactivity disorder, alcohol use, anxiety,and poor psychosocial support.
  • Neurobiological evidence suggests a dual processing model of digital technology addictions characterized by an imbalance between the reactive reward system and the reflective reward system
Summary

In spite of the lack of a consensus on diagnosis, and the resulting variations in epidemiologic, comorbidity, and neurobiological research, these studies provide overwhelming evidence of similarities between IVGA and SUD. Taken as a whole, the research presented here strongly suggests that IVGA is a clinically relevant and valid syndrome. Like other addictions, it is better understood when incorporating a neuro-biological perspective. Our field must successfully address IVGAs to meet the needs of a society that is increasingly enmeshed in digital technology. Research in this area should continue to accelerate, allowing clinicians to better screen for, diagnose, psycho-educate, and provide multimodal treatment for our patients with IVGA. Treatment of IVGAs is explored in David N. Greenfield’s article, “Treatment Considerations in Internet and Video Game Addiction: A Qualitative Discussion,” in this issue.

Significant limitations in the current body of research include the difficulty in determining causality among many epidemiologic correlations, the limited knowledge of brain changes occurring in IVGA, including whether they are reversible, and the absence of animal model studies. These weaknesses will likely continue to encourage challenges to the validity of IVGA from critics. Some argue that digital technology use is so pervasive that the diagnosis may overpathologize behavior that is normative and acceptable in our culture.105 On the other hand, modern society’s excessive engagement with technology risks falsely normalizing addictions to technology, in what may be a culture of “functional tech-oholics.” It seems difficult to walk down a public street without seeing multiple passersby engaged with smartphones, or to partake in a group conversation with no mention of digital media in some form. It seems evident that the human brain cannot evolve fast enough to adapt to the progress of digital technology, and that even the most powerful prefrontal cortex may be unable to resist the allure of instant stimulation in the ocean of digital screens that our world is becoming. Regardless of where we place the diagnostic cutoff for IVGA, our patients suffering the most profound dysfunction from their use of digital technology need better resources to recognize, understand, and treat their condition. If IVGA proves to be more abundant than a collection of a few extreme cases, it will be even more vital for our psychoeducational interventions to reach not only affected individuals, but their families and the communities as well. Ironically, social media and other forms of screen-based education may prove the best platforms for reaching out to those suffering IVGA without the insight, knowledge, and resources to address it.a This fact reminds us that learning more about the benefits of digital technology as well as its risks represents a challenge for modern providers and an opportunity for contemporary researchers.

http://bit.ly/intaddicSussman2018

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Cheng YS, Tseng PT, Lin PY, Chen TY, Stubbs B, Carvalho AF, Wu CK, Chen YW, Wu MK. Internet Addiction and Its Relationship With Suicidal Behaviors: A Meta-Analysis of Multinational Observational Studies. J Clin Psychiatry. 2018 Jun 5;79(4). pii: 17r11761.

Abstract

OBJECTIVE: To perform a systematic review and meta-analysis of observational studies that investigated the putative association between internet addiction and suicidality.

DATA SOURCES: Major electronic databases (PubMed, Embase, ClinicalKey, Cochrane Library, ProQuest, Science Direct, and ClinicalTrials.gov) were searched using the following keywords (internet addiction OR internet gaming disorder OR internet use disorder OR pathological internet use OR compulsive internet use OR problematic internet use) AND (suicide OR depression) to identify observational studies from inception to October 31, 2017.

STUDY SELECTION: We included 23 cross-sectional studies (n = 270,596) and 2 prospective studies (n = 1,180) that investigated the relationship between suicide and internet addiction.

DATA EXTRACTION: We extracted the rates of suicidal ideation, planning, and attempts in individuals with internet addiction and controls.

RESULTS: The individuals with internet addiction had significantly higher rates of suicidal ideation (odds ratio [OR] = 2.952), planning (OR = 3.172), and attempts (OR = 2.811) and higher severity of suicidal ideation (Hedges g = 0.723). When restricted to adjusted ORs for demographic data and depression, the odds of suicidal ideation and attempts were still significantly higher in the individuals with internet addiction (ideation: pooled adjusted OR = 1.490; attempts: pooled adjusted OR = 1.559). In subgroup analysis, there was a significantly higher prevalence rate of suicidal ideation in children (age less than 18 years) than in adults (OR = 3.771 and OR = 1.955, respectively).


CONCLUSIONS: This meta-analysis provides evidence that internet addiction is associated with increased suicidality even after adjusting for potential confounding variables including depression. However, the evidence was derived mostly from cross-sectional studies. Future prospective studies are necessary to confirm these findings.


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Fumero A, Marrero RJ, Voltes D, Peñate  W. Personal and social factors involved in internet addiction among adolescents: A meta-analysis. Computers in Human Behavior. 86:387-400. Sep 2018. https://doi.org/10.1016/j.chb.2018.05.005

Highlights

• Internet addiction (IA) was associated with psychosocial factors in adolescents.
• The risk factors had a greater effect on IA than protective factors.
• Personal factors showed a greater association with IA than social factors.
• Hostility, depression and anxiety showed the greatest link with IA.

Abstract

Background and Aims  The growing popularity and frequency of Internet use has resulted in a large number of studies reporting various clinical problems associated with its abuse. The main purpose of this study is to conduct a meta-analysis of the association between Internet addiction (IA) and a number of personal and social psychological factors in adolescents.

Methods  The search included cross-sectional, case-control and cohort studies which analyzed the relationship between IA and at least one of the following personal variables: (i) psychopathology, (ii) personality features and (iii) social difficulties, as well as (iv) self-esteem, (v) social skills and (vi) positive family functioning. These variables were classified as protective and promoting factors of the risk of developing IA.

Results  A total of 28 studies with adequate methodological quality were identified in the primary medical, health and psychological literature databases up to November 2017. Of the 48,090 students included in the analysis, 6548 (13.62%) were identified as excessive Internet users. The results highlight that risk factors had a greater effect on IA than protective factors. Also, personal factors showed a greater link with IA than social factors.

Conclusions  The data provide relevant information for those developing programs for the prevention of IA and the enhancement of protective factors.


https://www.sciencedirect.com/science/article/pii/S0747563218302310


Social Networking Site Disorder


Social Media Use and Its Link to Physical Health Indicators

David S. Lee, Tao Jiang, Jennifer Crocker, Baldwin M. Way. Social Media Use and Its Link to Physical Health Indicators. Cyberpsychology, Behavior, and Social Networking.12 Jan 2022. doi:10.1089/cyber.2021.0188

Abstract

Social media use has become an integral part of many young adults' daily lives. Although much research has examined how social media use relates to psychological well-being, little is known about how it relates to physical health. To address this knowledge gap, the present research investigated how the amount of social media people use relates to various indices of physical health. Young adults provided a blood sample that was analyzed for C-reactive protein (CRP), a marker of chronic inflammation. They also completed self-report measures of social media use, somatic symptoms, illness-related physician or health center visits, and whether they sought medical care for infection-related illnesses in the last 3 months.

Social media use was positively correlated with higher levels of CRP, more somatic symptoms, and more visits to the doctor or health centers for an illness. Although directionally consistent, the correlation with likelihood of seeking medical care for infection-related illnesses was nonsignificant (p = 0.061). All of these results held after controlling for factors such as sociodemographic information and depressive symptoms. Given the prevalence of social media use in daily life, these findings underscore the need for more research examining how social media use relates to physical health.

Open access paper: https://www.liebertpub.com/doi/10.1089/cyber.2021.0188

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Hunt MG, Marx R, Lipson C, Young J. No More FOMO: Limiting social media decreases loneliness and depression. Journal of Social and Clinical Psychology. 37(10): 751-768. 2018. doi:10.1521/jscp.2018.37.10.751.

Abstract

Introduction: Given the breadth of correlational research linking social media use to worse well-being, we undertook an experimental study to investigate the potential causal role that social media plays in this relationship.

Method: After a week of baseline monitoring, 143 undergraduates at the University of Pennsylvania were randomly assigned to either limit Facebook, Instagram and Snapchat use to 10 minutes, per platform, per day, or to use social media as usual for three weeks.

Results: The limited use group showed significant reductions in loneliness and depression over three weeks compared to the control group. Both groups showed significant decreases in anxiety and fear of missing out over baseline, suggesting a benefit of increased self-monitoring.

Discussion: Our findings strongly suggest that limiting social media use to approximately 30 minutes per day may lead to significant improvement in well-being.

Conclusion

Most of the prior research that has been done on social media and well-being has been correlational in nature. A few prospective and experimental studies have been done, but they have only focused on Facebook. Our study is the first ecologically valid, experimental investigation that examines multiple social media platforms and tracks actual usage objectively. The results from our experiment strongly suggest that limiting social media usage does have a direct and positive impact on subjective well- and depression. That is, ours is the first study to establish a clear causal link between decreasing social media use, and improvements in loneliness and depression. It is ironic, but perhaps not surprising, that reducing social media, which promised to help us connect with others, actually helps people feel less lonely and depressed. 


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Pontes HM. Investigating the differential effects of social networking site addiction and Internet gaming disorder on psychological health. J Behav Addict. 2017 Nov 13:1-10. doi: 10.1556/2006.6.2017.075.

Abstract

Background and aims: Previous studies focused on examining the interrelationships between social networking site (SNS) addiction and Internet gaming disorder (IGD) in isolation. Moreover, little is known about the potential simultaneous differential effects of SNS addiction and IGD on psychological health. This study investigated the interplay between these two technological addictions and ascertained how they can uniquely and distinctively contribute to increasing psychiatric distress when accounting for potential effects stemming from sociodemographic and technology-related variables.

Methods: A sample of 509 adolescents (53.5% males) aged 10-18 years (mean = 13.02, SD = 1.64) were recruited.

Results: It was found that key demographic variables can play a distinct role in explaining SNS addiction and IGD. Furthermore, it was found that SNS addiction and IGD can augment the symptoms of each other, and simultaneously contribute to deterioration of overall psychological health in a similar fashion, further highlighting potentially common etiological and clinical course between these two phenomena. Finally, the detrimental effects of IGD on psychological health were found to be slightly more pronounced than those produced by SNS addiction, a finding that warrants additional scientific scrutiny.

Discussion and conclusion: The implications of these results are further discussed in light of the existing evidence and debates regarding the status of technological addictions as primary and secondary disorders.



Internet Gaming Disorder/Addiction


Gaming disorder

World Health Organization, January 2018
What is gaming disorder?
Gaming disorder is defined in the draft 11th Revision of the International Classification of Diseases (ICD-11) as a pattern of gaming behavior (“digital-gaming” or “video-gaming”) characterized by impaired control over gaming, increasing priority given to gaming over other activities to the extent that gaming takes precedence over other interests and daily activities, and continuation or escalation of gaming despite the occurrence of negative consequences.
For gaming disorder to be diagnosed, the behaviour pattern must be of sufficient severity to result in significant impairment in personal, family, social, educational, occupational or other important areas of functioning and would normally have been evident for at least 12 months.
What is the International Classification of Diseases?
The International Classification of Diseases (ICD) is the basis for identification of health trends and statistics globally and the international standard for reporting diseases and health conditions. It is used by medical practitioners around the world to diagnose conditions and by researchers to categorize conditions.
The inclusion of a disorder in ICD is a consideration which countries take into account when planning public health strategies and monitoring trends of disorders.
WHO is working on updating of the ICD. The 11th revision of the International Classification of Diseases (ICD-11) is scheduled for publication in mid-2018.
Why is gaming disorder being included in ICD-11?
A decision on inclusion of gaming disorder in ICD-11 is based on reviews of available evidence and reflects a consensus of experts from different disciplines and geographical regions that were involved in the process of technical consultations undertaken by WHO in the process of ICD-11 development.
The inclusion of gaming disorder in ICD-11 follows the development of treatment programmes for people with health conditions identical to those characteristic of gaming disorder in many parts of the world, and will result in the increased attention of health professionals to the risks of development of this disorder and, accordingly, to relevant prevention and treatment measures.
Should all people who engage in gaming be concerned about developing gaming disorder?
Studies suggest that gaming disorder affects only a small proportion of people who engage in digital- or video-gaming activities. However, people who partake in gaming should be alert to the amount of time they spend on gaming activities, particularly when it is to the exclusion of other daily activities, as well as to any changes in their physical or psychological health and social functioning that could be attributed to their pattern of gaming behaviour.

http://www.who.int/features/qa/gaming-disorder/en/

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Park CH, Chun JW, Cho H, Kim DJ. Alterations in the connection topology of brain structural networks in Internet gaming addiction. Sci Rep. 2018 Oct 11;8(1):15117. doi: 10.1038/s41598-018-33324-y.

Abstract

Internet gaming addiction (IGA), as the most popular subtype of Internet addiction, is becoming a common and widespread mental health concern, but there are still debates on whether IGA constitutes a psychiatric disorder. The view on the brain as a complex network has developed network analysis of neuroimaging data, revealing that abnormalities of brain functional and structural systems are related to alterations in brain network configuration, such as small-world topology, in neuropsychiatric disorders. Here we applied network analysis to diffusion-weighted MRI data of 102 gaming individuals and 41 non-gaming healthy individuals to seek changes in the small-world topology of brain structural networks in IGA. The connection topology of brain structural networks shifted to the direction of random topology in the gaming individuals, irrespective of whether they were diagnosed with Internet gaming disorder. Furthermore, when we simulated targeted or untargeted attacks on nodes, the connection topology of the gaming individuals' brain structural networks under no attacks was comparable to that of the non-gaming healthy individuals' brain structural networks under targeted attacks. Alterations in connection topology provide a clue that Internet gaming addicted brains could be as abnormal as brains suffering from targeted damage. 

Open access paper: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182010/

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Wang HR, Cho H, Kim DJ. Prevalence and correlates of comorbid depression in a nonclinical online sample with DSM-5 internet gaming disorder. J Affect Disord. 2018 Jan 15;226:1-5. doi: 10.1016/j.jad.2017.08.005.
Abstract
BACKGROUND: We investigated the prevalence and correlates of comorbid depression among patients with internet gaming disorder using the Internet Gaming Disorder scale (IGD-9) and the Patient Health Questionnaire-9 (PHQ-9) among nonclinical online survey respondents
METHODS: Korean adolescents and adults from 14 to 39 years of age were selected. We compared internet gaming use patterns and sociodemographic and clinical variables between patients with internet gaming disorder who had depression and those without depression.
RESULTS: In 2016, 7200 people participated in an online survey. Respondents with internet gaming disorder that was comorbid with depression were older, more often female, had greater Internet Addiction Test total scores, Alcohol Use Disorder Identification Test total scores, Generalized Anxiety Disorder Scale-7 total scores, Fagerstrom Test for Nicotine Dependence total scores, and higher Dickman Dysfunctional Impulsivity Instrument dysfunctional subscale scores than those without depression. The binary logistic regression analysis revealed that female gender, problematic alcohol use, anxiety, and a past history of psychiatric counseling or treatment due to internet gaming use were significant predictors for comorbid depression among participants with internet gaming disorder.
CONCLUSION: Depression was a common comorbidity of internet gaming disorder. Internet gaming disorder with comorbid depression was related to more serious psychiatric phenomenology and a greater psychiatric burden.


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Stockdale L, Coyne SM. Video game addiction in emerging adulthood: Cross-sectional evidence of pathology in video game addicts as compared to matched healthy controls. J Affect Disord. 2018 Jan 1;225:265-272. doi: 10.1016/j.jad.2017.08.045.

Abstract

BACKGROUND: The Internet Gaming Disorder Scale (IGDS) is a widely used measure of video game addiction, a pathology affecting a small percentage of all people who play video games. Emerging adult males are significantly more likely to be video game addicts. Few researchers have examined how people who qualify as video game addicts based on the IGDS compared to matched controls based on age, gender, race, and marital status.

METHOD: The current study compared IGDS video game addicts to matched non-addicts in terms of their mental, physical, social-emotional health using self-report, survey methods.

RESULTS: Addicts had poorer mental health and cognitive functioning including poorer impulse control and ADHD symptoms compared to controls. Additionally, addicts displayed increased emotional difficulties including increased depression and anxiety, felt more socially isolated, and were more likely to display internet pornography pathological use symptoms. Female video game addicts were at unique risk for negative outcomes.

LIMITATIONS: The sample for this study was undergraduate college students and self-report measures were used.

CONCLUSIONS: Participants who met the IGDS criteria for video game addiction displayed poorer emotional, physical, mental, and social health, adding to the growing evidence that video game addictions are a valid phenomenon.


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Paik SH, Cho H, Chun JW, Jeong JE, Kim DJ. Gaming Device Usage Patterns Predict Internet Gaming Disorder: Comparison across Different Gaming Device Usage Patterns. Int J Environ Res Public Health. 2017 Dec 5;14(12). pii: E1512. doi: 10.3390/ijerph14121512.

Abstract

Gaming behaviors have been significantly influenced by smartphones. This study was designed to explore gaming behaviors and clinical characteristics across different gaming device usage patterns and the role of the patterns on Internet gaming disorder (IGD). Responders of an online survey regarding smartphone and online game usage were classified by different gaming device usage patterns: (1) individuals who played only computer games; (2) individuals who played computer games more than smartphone games; (3) individuals who played computer and smartphone games evenly; (4) individuals who played smartphone games more than computer games; (5) individuals who played only smartphone games. Data on demographics, gaming-related behaviors, and scales for Internet and smartphone addiction, depression, anxiety disorder, and substance use were collected. Combined users, especially those who played computer and smartphone games evenly, had higher prevalence of IGD, depression, anxiety disorder, and substance use disorder. These subjects were more prone to develop IGD than reference group (computer only gamers) (B = 0.457, odds ratio = 1.579). Smartphone only gamers had the lowest prevalence of IGD, spent the least time and money on gaming, and showed lowest scores of Internet and smartphone addiction. Our findings suggest that gaming device usage patterns may be associated with the occurrence, course, and prognosis of IGD.


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Du X, Yang Y, Gao P, Qi X, Du G, et al. Compensatory increase of functional connectivity density in adolescents with internet gaming disorder. Brain Imaging Behav. 2017 Dec;11(6):1901-1909. doi: 10.1007/s11682-016-9655-x.

Abstract

Behavioral studies have demonstrated visual attention bias and working memory deficits in individuals with internet gaming disorder (IGD). Neuroimaging studies demonstrated that individuals with IGD presented abnormalities in brain structures and functions including resting-state functional connectivity (rsFC) disturbance. However, most previous studies investigated IGD-related rsFC alterations by using hypothesis-driven methods with priori selection of a region of interest, which cannot provide a full picture of the rsFC changes in IGD individuals. In this study, we recruited 27 male IGD adolescents and 35 demographically matched healthy controls (HCs) to investigate abnormal connective property of each voxel within whole brain of IGD adolescents using resting-state functional connectivity density (rsFCD) method, and further to evaluate the relationship between altered rsFCD and behavioral performances of visual attention and working memory. The results exhibited no significant intergroup difference in behavioral performance (visual working memory and attention). The IGD adolescents exhibited higher global/long-range rsFCD in the bilateral dorsal lateral prefrontal cortex (DLPFC) and the right inferior temporal cortex (ITC)/fusiform compared with the HCs. Although no significant correlation survived after Bonferroni correction, higher global/long-range rsFCD of the bilateral DLPFC was correlated with the Young's internet addiction test (IAT) score and/or behavioral performance in IGD adolescents using an uncorrected threshold of P < 0.05. In conclusion, IGD adolescents demonstrated increased rsFCD in the brain regions involved in working memory, spatial orientation and attention processing, which indicated that increased rsFCD may reflect a compensatory mechanism for maintaining the normal behavioral performance in IGD adolescents compared with the HCs.


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Zhai J, Luo L, Qiu L, Kang Y, Liu B, et al. The topological organization of white matter network in internet gaming disorder individuals. Brain Imaging Behav. 2017 Dec;11(6):1769-1778. doi: 10.1007/s11682-016-9652-0.

Abstract

White matter (WM) integrity abnormalities had been reported in Internet gaming disorder (IGD). Diffusion tensor imaging (DTI) tractography allows identification of WM tracts, potentially providing information about the integrity and organization of relevant underlying WM fiber tracts' architectures, which has been used to investigate the connectivity of cortical and subcortical structures in several brain disorders. Unfortunately, relatively little is known about the thoroughly circuit-level characterization of topological property changes of WM network with IGD. Sixteen right-hand adolescents with IGD participated in our study, according to the diagnostic criteria of IGD in DSM-5. Meanwhile, 16 age and gender-matched healthy controls were also enrolled. DTI tractography was employed to generate brain WM networks in IGD individuals and healthy controls. The 90 cortical and subcortical regions derived from AAL template were chosen as the nodes. The network parameters (i.e., Network strength, clustering coefficient, shortest path length, global efficiency, local efficiency, regional efficiency) were calculated and then correlated with the Internet addiction test (IAT) scores in IGD. IGD group showed decreased global efficiency, local efficiency and increased shortest path length. Further analysis revealed the reduced nodal efficiency in frontal cortex, anterior cingulate cortex and pallidium in IGD. In addition, the global efficiency of WM network was correlated with the IAT scores in IGD (r = -0.5927; p = 0.0155). We reported the abnormal topological organization of WM network in IGD and the association with the severity of IGD, which may provide new insights into the neural mechanism of IGD from WM network level.

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Zajac K, Ginley MK, Chang R, Petry NM. Treatments for Internet gaming disorder and Internet addiction: A systematic review. Psychol Addict Behav. 2017 Dec;31(8):979-994. doi: 10.1037/adb0000315. Epub 2017 Sep 18.

Abstract

Problems related to excessive use of the Internet and video games have recently captured the interests of both researchers and clinicians. The goals of this review are to summarize the literature on treatment effectiveness for these problems and to determine whether any treatments meet the minimum requirement of an evidence-based treatment as defined by Chambless et al. (1998). Studies of treatments for Internet gaming disorder (IGD) and Internet addiction were examined separately, as past studies have linked IGD to more severe outcomes. The systematic review identified 26 studies meeting predefined criteria; 13 focused on treatments for IGD and 13 on Internet addiction. The results highlighted a paucity of well-designed treatment outcome studies and limited evidence for the effectiveness of any treatment modality. Studies were limited by methodological flaws, including small sample sizes, lack of control groups, and little information on treatment adherence, among other problems. In addition, the field is beset by a lack of consistent definitions of and established instruments to measure IGD and Internet addiction. The results of this review highlight the need for additional work in the area of treatment development and evaluation for IGD and Internet addiction. Attention to methodological concerns identified within this review should improve subsequent research related to treating these conditions, and ultimately outcomes of patients suffering from them.