Friday, May 24, 2019

Trends in Brain Tumor Incidence Outside the U.S.

Incidence trends of adult malignant brain tumors in Finland, 1990-2016

Natukka T, Raitanen J, Haapasalo H, Auvinen A. Incidence trends of adult malignant brain tumors in Finland, 1990-2016. Acta Oncol. 2019 Apr 15:1-7. doi: 10.1080/0284186X.2019.1603396.


BACKGROUND: Several studies have reported increased incidence trends of malignant gliomas in the late 1900s with a plateau in the 2000s, but also some  recent increases have been reported. The purpose of our study was to analyze incidence trends of malignant gliomas in Finland by morphology and tumor location.

MATERIAL AND METHODS: Data on 4730 malignant glioma patients were obtained from case notifications to the nationwide, population-based Finnish Cancer Registry (FCR), and less detailed data on 3590 patients up to 2016. Age-standardized incidence rates (ASR) and average annual percent changes (APCs) in the incidence rates were calculated by histological subtype and tumor location.

RESULTS: The incidence rate of gliomas was 7.7/100,000 in 1990-2006 and 7.3 in 2007-2016. The incidence of all gliomas combined was stable during both study periods, with no departure from linearity. In an analysis by age group, increasing incidence was found only for ages 80 years and older (1990-2006). During both study periods, incidence rates were increasing in glioblastoma and decreasing in unspecified brain tumors. In 1990-2006, rates were also increasing for anaplastic oligodendroglioma, oligoastrocytoma and unspecified malignant glioma, while decreasing for astrocytoma. As for tumor location, incidence in 1990-2006 was increasing for frontal lobe and brainstem tumors, as well as those with an unspecified location, but decreasing for the parietal lobes, cerebrum and ventricles.

CONCLUSIONS: No increasing incidence trend was observed for malignant gliomas overall. An increasing incidence trend of malignant gliomas was found in the oldest age group during 1990-2006.


The incidence trend of glioblastoma was slightly increasing (APC: +0.8%; 95% CI: 0.0, +1.7 for 1990–2006 and +1.9%; 95% CI: +0.2, +3.5 for 2007–2016; Tables 2 and

Incidence of glioblastoma increased slightly throughout the study period, while unspecified tumors of the brain showed a decreasing incidence trend.

We also found a slightly increasing incidence trend for the most common histological subtype, glioblastoma, which is consistent with several other studies [1,5,7–9,11,17,18]. A study from United States showed an increasing incidence trend for gliomas in the frontal lobe and decreasing trends for the cerebrum, ventricles and overlapping subtypes [17].


[1] Ostrom QT, Gittleman H, Liao P, et al. CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2010–2014. Neuro Oncol. 2017;19: v1–v88.
[5] Ho VKY, Reijneveld JC, Enting RH, et al. Changing incidence and improved survival of gliomas. Eur J Cancer. 2014;50:2309–2318.
[7] Arora RS, Alston RD, Eden TOB, et al. Are reported increases in incidence of primary CNS tumours real? An analysis of longitudinal trends in England, 1979–2003. Eur J Cancer. 2010;46: 1607–1616.
[8] Deorah S, Lynch CF, Sibenaller ZA, et al. Trends in brain cancer incidence and survival in the United States: surveillance, epidemiology, and end results program, 1973 to 2001. Neurosurg Focus. 2006;20:E1.
[9] Hess KR, Broglio KR, Bondy ML. Adult glioma incidence trends in the United States, 1977–2000. Cancer. 2004;101:2293–2299.
[11] Lonn S, Klaeboe L, Hall P, et al. Incidence trends of adult primary intracerebral tumors in four Nordic countries. Int J Cancer. 2004; 108:450–455.
[17] Zada G, Bond AE, Wang YP, et al. Incidence trends in the anatomic location of primary malignant brain tumors in the United States: 1992–2006. World Neurosurg. 2012;77:518–524.
[18] Dubrow R, Darefsky AS. Demographic variation in incidence of adult glioma by subtype, United States, 1992–2007. BMC Cancer. 2011;11:325.


Trends in the incidence of primary brain, central nervous system and intracranial tumors in Israel, 1990-2015

Keinan-Boker L, Friedman E, Silverman BG. Trends in the incidence of primary brain, central nervous system and intracranial tumors in Israel, 1990-2015. Cancer Epidemiol. 2018 Oct;56:6-13. doi: 10.1016/j.canep.2018.07.003.


• Exponential growth in cellphone use fueled concerns regarding brain and CNS tumors.
• Results so far are inconsistent. Studying cancer incidence trends may thus be informative.
• We studied brain tumor trends from 1990 to 2015 in Israel, when cellphone use dramatically increased.
• Results do not support a substantial role for cellphone use; smaller risks in special subgroups may exist.
• Future research is needed; implementation of the precautionary principle is prudent.


BACKGROUND: The association between cellphone technology and brain, central nervous system (CNS) and intracranial tumors is unclear. Analysis of trends in incidence of such tumors for periods during which cellphone use increased dramatically may add relevant information. Herein we describe secular trends in the incidence of primary tumors of the brain and CNS from 1990 to 2015 in Israel, a period during which cellphone technology became extremely prevalent in Israel.

METHODS: All cases of primary brain, CNS and intracranial tumors (excluding lymphomas) diagnosed in Israel from 1990 to 2015 were identified in the Israel National Cancer Registry database and categorized by behavior (malignant; benign/uncertain behavior) and histologic type. Annual age-standardized incidence rates by sex and population group (Jews; Arabs) were computed, and the annual percent changes and 95% confidence intervals per category were calculated using Joinpoint software.

RESULTS: Over 26 years (1990-2015) no significant changes in the incidence of malignant brain, CNS and intracranial tumors were observed, except for an increase in malignant glioma incidence in Jewish women up to 2008 and Arab men up to 2001, which levelled off in both subgroups thereafter. The incidence of benign/uncertain behavior brain, CNS and intracranial tumors increased in most population groups up to the mid-2000s, a trend mostly driven by changes in the incidence of meningioma, but either significantly decreased (Jews) or stabilized (Arabs) thereafter.

CONCLUSIONS: Our findings are not consistent with a discernable effect of cellphone use patterns in Israel on incidence trends of brain, CNS and intracranial tumors.


"When cancer occurrence rates referred to glioblastomas only, Joinpoint analysis of incidence trends was restricted to the period from 1995 to 2015 due to small numbers of cases in the Arab population prior to 1995. Stable incidence trends were noted, with non-significant APCs, in all population subgroups: APC1995–2015 for Jewish men was +0.6% (95%CI -0.4%,+1.6%); APC1995–2015 for Jewish women was +0.6% (95%CI -0.1%,+1.6%); APC1995–2015 for Arab men was -1.6% (95%CI -3.9%,+0.8%); APC1995–2015 for Arab women was +0.4% (95%CI -2.9%,+3.8%).

Analysis of time trends by age groups disclosed stable trends in most population- age- and sex groups, except for a mild increase in Jewish males aged 65 and over (APC1990–2015 +1.2%, p < 0.05) and in Arab males aged 20–64 (APC1990–2015 +1.5%, p < 0.05). In the population of Arab females, lack of cases in the age groups of 20–64 and 65+ in certain years prevented an analysis of trends."

"However, ecologic studies, of which ours is an example, may be insensitive to excess in risk which is restricted to certain groups (for example, heavy users or subjects exposed from very young ages) or to certain tumor types (e.g., tumors that are very rare, that involve specific anatomical sites, or that have unusually long latency periods) [34]. Little et al. [35] also commented that the predicted rates of glioma based on data derived from the small proportion of highly exposed people in the Interphone study, could be consistent with the observed rates in their study [35]. Therefore, although a substantial risk is not very plausible, smaller risks cannot be ruled out and future research should address specific exposure groups, and tumor types and sites, and should allow for longer follow up periods."


England: Brain Cancer Incidence Increased in Temporal and Frontal Lobes of Brain since 1995

A new study of cancer data in England essentially replicated the results of the Philips et al study (see below). The study found that the two age groups most vulnerable to carcinogenic effects from cell phone use -- young and elderly adults -- showed increased incidence over time in brain cancer in the frontal and temporal lobes of the brain -- the two lobes that receive the greatest dose of microwave radiation when cell phones are used near the head during phone calls.

However, Frank de Vocht, the author of this paper, rejected the explanation that cell phone use caused the increased cancer risk. He attributed the increased incidence to better diagnosis of brain tumors, especially in the elderly. Of course, this does not explain why the increase was only observed in the frontal and temporal lobes. He did not rule out the possibility that cell phone radiation may be a contributing factor to the observed increase.

Microwave News reported on this study and published the following graph obtained from Alasdair Philips (Microwave News, "Location, Location, Location: Aggressive Brain Tumors Tell a Story; GBM Rise Only in Frontal and Temporal Lobes, Oct 26, 2018.)

de Vocht F. Analyses of temporal and spatial patterns of Glioblastoma Multiforme and other brain cancers subtypes in relation to mobile phones using synthetic counterfactuals. Environmental Research. Available online 17 October 2018.


• English 1985–2005 brain cancer subtype rates were compared to counterfactual trends
• Excess GBM increases were found in the frontal and temporal lobes, and cerebellum
• Mobile phone use was unlikely to have been an important putative factor
• No evidence of an effect of mobile phone use on acoustic neuroma and meningioma


This study assesses whether temporal trends in glioblastoma multiforme (GBM) in different brain regions, and of different malignant and benign (including acoustic neuroma and meningioma) subtypes in the temporal lobe, could be associated with mobile phone use.

Annual 1985–2005 incidence of brain cancer subtypes for England were linked to population-level covariates. Bayesian structural timeseries were used to create 2006–2014 counterfactual trends, and differences with measured newly diagnosed cases were interpreted as causal effects.

Increases in excess of the counterfactuals for GBM were found in the temporal (+38% [95% Credible Interval -7%,78%]) and frontal (+36% [-8%,77%]) lobes, which were in agreement with hypothesised temporal and spatial mechanisms of mobile phone usage, and cerebellum (+59% [-0%,120%]). However, effects were primarily present in older age groups, with largest effects in 75+ and 85+ groups, indicating mobile phone use is unlikely to have been an important putative factor. There was no evidence of an effect of mobile phone use on incidence of acoustic neuroma and meningioma.

Although 1985–2014 trends in GBM in the temporal and frontal lobes, and probably cerebellum, seem consistent with mobile phone use as an important putative factor, age-group specific analyses indicate that it is unlikely that this correlation is causal.


Assessment of specific cancer subtypes in the temporal lobe indicated that the excess incidence was mainly found for GBM, with similar trends observed in the frontal lobe and cerebellum....  The increased rates of specific brain cancer subtypes in excess of the counterfactuals correspond to the spatial and temporal patterns that would be expected if exposure to RF from mobile phones were an important putative factor (Cardis et al., 2008, Morgan et al., 2016) ... However, age group-specific analyses indicate that the excess relative impacts increased with age over 65 years and were primarily found in the very old (75/85+ years of age) for whom it is unlikely that mobile phone use had been an important causal factor. In addition, excess numbers of newly diagnosed cases were also observed in the young (<24 years of age) for whom mobile phone use is also an unlikely causal factor....

The assumption that a 10-year lag was the most plausible period between first exposure and when increased risk could be observed in registry data was based on the previous analyses (De Vocht (2016)). Although sensitivity analysis using a 15-year lag showed no evidence of excesses relative to counterfactuals, this may still have been too short....
This study, in agreement with other data from the UK and elsewhere, shows that the incidence of glioblastoma multiforme (astrocytoma grade IV) has increased significantly since the 1980s, especially in the frontal and temporal lobes and cerebellum. However, it further provides evidence that the trend of increasing numbers of newly diagnosed cases of glioblastoma multiforme in the temporal lobe (but likely in the frontal lobe and cerebellum as well) since the mid-1980s, although seemingly consistent with the hypothesis of exposure to radiofrequency radiation from mobile phones being an important putative factor, should to a large extent (if not exclusively) be attributed to another factor or factors; of which improvements in diagnostic techniques, especially in the elderly, seems the most plausible. Although these analyses indicate that it is unlikely that exposure to RF from mobile phones is an important putative factor, they also cannot exclude it as a contributing factor completely. It is therefore important to keep monitoring incidence trend data.

Competing financial interests declaration: The author has previously done consulting for EPRI [Electric Power Research Institute], not related to this work. 

Financial support: No external funding was obtained for this study.

Mar 25, 2018

England: Rates of Aggressive Brain Cancer Increased from 1995 to 2014

A newly-published study of brain tumor incidence trends in England from 1995 to 2014 found that the trends over time varied by type of cancer, especially in the frontal and temporal lobes.

The study found “a sustained and highly statistically significant” increase in glioblastoma multiforme (GBM), the most common brain cancer, across all ages. The rate of GBM more than doubled from 2.4 to 5.0 per 100,000 people. However, this increase was mostly hidden because the overall malignant brain tumor trend was relatively flat due to a reduced incidence of lower grade brain tumors.

In England in 1995, when the tumor site was specified at the time of diagnosis, the frontal or temporal lobes of the brain accounted for 41% of malignant brain tumors. By 2015, these two sites accounted for 60% of the tumors.

One cannot know from tumor registry data alone what caused these differential trends in brain cancer. Based upon epidemiologic research, the most compelling explanation for the increased incidence in these deadly brain tumors, especially in the frontal and temporal lobes, may be exposure to microwave radiation due to widespread adoption of cell phones. However, the increased use of CT imaging scans is an alternative, but less compelling, explanation because far fewer people would have been exposed to this form of ionizing radiation.

In the U.S., Zada and his colleagues (2012) obtained similar results in an analysis of national tumor registry data from 1992 to 2006.

Those who cite statistics which appear to show a flat-line trend in overall brain tumor incidence and argue that cell phone use doesn’t cause brain cancer need to examine data on the location and type of brain tumors over time.

Also see:

Microwave News. “Aggressive Brain Tumors on the Rise in England.” March 25, 2018.

Source: Alasdair Philips via Microwave News.


Brain tumours: rise in Glioblastoma Multiforme incidence in England 1995–2015 suggests an adverse environmental or lifestyle factor

Alasdair Philips, Denis L. Henshaw, Graham Lamburn, and Michael O'Carroll. Brain tumours: rise in Glioblastoma Multiforme incidence in England 1995–2015 suggests an adverse environmental or lifestyle factor. Journal of Environmental and Public HealthArticle ID 7910754, 2018.


• A clear description of the changing pattern in incidence of brain tumour types
• The study used extensive data from an official and recognised quality source
• The study included histological and morphological information
• The study identified a significant and concerning incidence time trend
• Some evidence is provided to help guide future research into causal mechanisms


Objective To investigate detailed trends in malignant brain tumour incidence over a recent time period.

Methods UK Office of National Statistics (ONS) data covering 81,135 ICD10 C71 brain tumours diagnosed in England (1995–2015) were used to calculate incidence rates (ASR) per 100k person–years, age–standardised to the European Standard Population (ESP–2013).

Results We report a sustained and highly statistically significant ASR rise in glioblastoma multiforme (GBM) across all ages. The ASR for GBM more than doubled from 2.4 to 5.0, with annual case numbers rising from 983 to 2531. Overall, this rise is mostly hidden in the overall data by a reduced incidence of lower grade tumours.

Conclusions The rise is of importance for clinical resources and brain tumour aetiology. The rise cannot be fully accounted for by promotion of lower–grade tumours, random chance or improvement in diagnostic techniques as it affects specific areas of the brain and only one type of brain tumour. Despite the large variation in case numbers by age, the percentage rise is similar across the age groups which suggests widespread environmental or lifestyle factors may be responsible.


1/. We show a linear, large and highly statistically significant increase in primary GBM tumours over 21 years from 1995–2015, especially in frontal and temporal lobes of the brain. This has aetiological and resource implications.
2/. Although most of the cases are in the group over 54 years of age, the age–standardised AAPC rise is strongly statistically significant in all our three main analysis age groups.

3/. The rise in age–standardised incidence cannot be fully accounted for by improved diagnosis as it affects specific areas of the brain and just one type of brain tumour which is generally fatal. We suggest that widespread environmental or lifestyle factors may be responsible.

4/. Our results highlight an urgent need for funding more research into the initiation and promotion of GBM tumours. This should include the use of CT imaging for diagnosis and also modern lifestyle factors that may affect tumour metabolism.

Thursday, May 23, 2019

5G Day of Action

5G Day of Action Rally, Wisconsin for Safe Technology, Greendale, Wisconsin

The Americans for Responsible Technology (ART), an association of more than 90 organizations, coordinated a nationwide day of action on May 15, 2019 to protest the deployment of 5G in the United States.

The purpose of the demonstrations was to raise public awareness about the health risks from 5G radiation and to place the burden of responsibility on those who stand to profit from 5G deployment.

ART and more than 30 local wireless safety groups called on wireless companies (Verizon, Sprint, AT&T and T-Mobile) and their sub-contractors (e.g, Crown Castle, American Tower, ExteNet Systems) to suspend the deployment of small cell antennas until chronic, low level exposure to 5G radio frequency radiation can be proven safe for everyone.

The local sponsors and locations of thirty demonstrations that occurred in fourteen states are listed below. A few other demonstrations do not appear in this list (e.g., Berkeley, CA; Oakland, CA).

California Brain Tumor Association, Burbank, CA
Ventura County Issues Reform, Calabasas, CA
Napa Neighborhood Association for Safe Technology, Napa, CA
Center for Electrosmog Prevention, San Diego, CA
San Francisco State University, San Francisco, CA
EMF Safety Network, San Rafael, CA
EMF Safety Network, Sebastopol, CA 
Ventura County Issues Reform, Simi Valley, CA
Concerned Citizens Against 5G, Stockton, CA
Ventura County Issues Reform, Thousand Oaks, CA
Danville Citizens for Responsible Growth, Walnut Creek, CA

Keep Your Power, Kahului, HI

Stop 5G Chicago, Chicago, IL

What is 5G?, Bethesda, MD

Centerville Concerned Citizens, Hyannis, MA
Last Tree Laws, Northampton, MA

Safe Tech Forward, Detroit, MI
Stop 5G MI, Petoskey, MI

North Carolina
Safe Tech Kids, Asheville, NC
Triangle Citizens for Safe Technology, Durham, NC

New York
Citizens for 5G Awareness, East Northport, NY
5G Wake Up Call, Manhattan, NY
Stop Smart Meters, Woodstock, NY

Oregon for Safer Technology, Ashland, OR
Oregon Institute for Creative Research, Portland, OR

5G Free, Harrisburg, PA

South Carolina
Stop 5G Greenville, Greenville, SC

EMF Safety for Vermont, Brattleboro, VT

Citizens of Tacoma Against 5G Small Cells in Residential Areas, Tacoma, WA

Wisconsin for Safe Technology, Greendale, WI

News Media Coverage of 5G Day of Action


Marin activists rally against 5G
Marin Independent Journal, May 15, 2019

Protesters rally against 5G in San Diego
KGTV (San Diego, CA), May 15, 2019 (ABC)

Photo Gallery: Locals protest against 5G at AT&T

Protesters voice opposition to 5G telecommunication devices
Los Angeles Times, May 17, 2019

Group protests 5G, doesn’t want it on Kauai
The Garden Island, May 16, 2019


Activists protest against 5G towers
WDVM (Montgomery County, MD), May 15, 2019

5G health fears exist but NYT & WSJ blame them on RT
RT America (reported on rally in Bethesda, MD), May 15, 2019

Protestors keep up fight against wireless technology

Rally seeking scrutiny of new 5G wireless
Cape Cod Times (Hyannis, MA), May 15, 2019

New York

Long Islanders Join Nationwide Anti-5G Rally
Long Island Press, May 16, 2019

North Carolina

Local group rallies in Asheville as part of national protest over 5G technology
WLOS (Asheville, NC), May 15, 2019  (ABC)


Locals plan rally against 5G rollout
KOBI / KOTI (Medford, OR), May 15, 2019  (NBC)
5G cell tower protest in Ashland
KTVL (Ashland, OR), May 15, 2019  (CBS)

Group rallies against 5G roll out
KDRV (Medford, OR), May 15, 2019  (ABC)

Locals plan rally against 5G rollout
KMVU (Medford, OR), May 15, 2019  (Fox)


Protesters push public notification on harms of cell tower radiation
Summerland Review (Summerland, British Columbia), May 15, 2019


Related Posts on Electromagnetic Radiation Safety

Wednesday, May 1, 2019

PowerWatch: 1,670 Scientific Papers on Electromagnetic Fields

This list is a compilation of citations for 1,670 peer-reviewed papers about electromagnetic fields (EMF) published in scientific journals from 1979 through 2018. The list includes all papers that PowerWatch published on its website as of October 11, 2018.

This is not a comprehensive list of studies. PowerWatch selected these studies from their internal database of 15,000 (approx.) scientific papers, most of which address EMF. 

Powerwatch has been researching the links between EMF and health risks for more than 25 years. The organization, which is completely independent of government and industry, gathers information to help the lay person understand this issue. For more information about PowerWatch go to:

Powerwatch recently added a search engine to its website which enables the user to search specific fields in their database for specified time periods.

This list is published on the Electromagnetic Radiation Safety website with the permission of Alasdair Philips, the Science Director and co-founder of PowerWatch.

Table of Contents

Mobile and Cordless Phones (pp. 2-29) -- 525 papers (P=306, N=100, - =119)

Mobile Phone Masts (pp. 30-35) -- 94 papers (P=39, N=10, - =45) 

Wi-Fi (pp. 36-38) -- 38 papers (P=13, N=3, - =22) 

Radio Transmitters (pp. 39-41) -- 43 papers (P=36, N=2, - =5) 

EEG and Brain Responses (pp. 65-67) -- 53 papers (P=48, N=2, - =3) 

Electrical Sensitivity (pp. 60-64) -- 88 papers (P=41, N=23, - =24)

Radiofrequency EMF Mechanisms (pp. 68-81) -- 251 papers (P=185, N=37, - =29)

Powerline Frequencies (pp. 42-59) -- 333 papers

Powerfrequency EMF Mechanisms (pp. 82-95) -- 256 papers

Click on the following link to download the 95-page list (pdf):

Related Posts: