Tuesday, December 13, 2016

Cell Phone Use and Salivary Gland Tumor Risk

Does cell phone use increase the chances of parotid gland tumor development?
A systematic review and meta-analysis

de Siqueira EC, de Souza FT, Gomez RS, Gomes CC, de Souza RP. Does cell phone use increase the chances of parotid gland tumor development? A systematic review and meta-analysis. J Oral Pathol Med. 2016 Dec 9. doi: 10.1111/jop.12531. [Epub ahead of print]

Abstract

BACKGROUND: Prior epidemiological studies had examined the association between cell phone use and the development of tumors in the parotid glands. However there is no consensus about the question of whether cell phone use is associated with increased risk of tumors in the parotid glands. We performed a meta-analysis to evaluate the existing literature about the mean question and to determine their statistical significance.

METHODS: Primary association studies. Papers that associated cell phone use and parotid gland tumors development were included, with no restrictions regarding publication date, language and place of publication. Systematic literature search using PubMed, Scielo and Embase followed by meta-analysis.

RESULTS AND CONCLUSION: Initial screening included 37 articles and three were included in meta-analysis. Using three independent samples including 5087 subjects from retrospective case-control studies, cell phone use seems to be associated with greater odds (1.28, 95%- confidence interval 1.09 - 1.51) to develop salivary gland tumor. Results should be read with caution due to the limited number of studies available and their retrospective design.

http://bit.ly/2gFfUBh
Excerpts

Salivary gland tumors are relatively rare, accounting for 2-5% of all head and neck tumors, being the parotids the most affected salivary gland (6).

We further evaluated the levels of inflammatory cytokines in the saliva produced by the parotids according to self-reported exposure to cell phone, reporting an increase in pro-inflammatory and a decrease of anti-inflammatory cytokine levels in the sample evaluated, suggesting a pro-inflammatory effect of cell phones (8).

Cell phone use was associated with greater odds (increase of 28%) of presence of tumor in the parotid glands (O.R. 1.28 95% C.I. [1.09–1.51] p = 0.0025) (Figure 2).

Primary association studies have reported discordant results (3, 5, 10, 12, 14, 15). Possible explanations for conflicting results are differences in study design, genetic background of sampled populations or clinical-epidemiological sample structure. It is important to note that discordant results do not mean that some are incorrect. Tumor manifestation is clearly a multifactorial process whose risk factors are several. Most of the studies have not assessed other risk factors when estimating existence of association.

This is the first systematic review followed by a meta-analysis to evaluate that association. Here, we report usage of cell phone increase, on average, 28% the odds of presenting parotid glands tumors.

Our results need to be read and interpreted with caution due to important limitations that need to be addressed. Although the number of subjects compiled is reasonably large, the number of independent samples is small (n = 3) and results are clearly driven by two of three studies.

Conclusion

Taken together, our results provide evidence of association between cell phone use and parotid tumor although their association presents mild effect.


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Histological and histochemical study of the protective role of rosemary extract against harmful effect of cell phone electromagnetic radiation on the parotid glands

Fatma M. Ghoneim, Eetmad A. Arafat. Histological and histochemical study of the protective role of rosemary extract against harmful effect of cell phone electromagnetic radiation on the parotid glands. Acta Histochemica, 118(5):478-485. June 2016.

Abstract

Electromagnetic fields (EMFs) are a class of non-ionizing radiation (NIR) that is emitted from mobile phone. It may have hazardous effects on parotid glands. So, we aimed to investigate the histological and histochemical changes of the parotid glands of rats exposed to mobile phone and study the possible protective role of rosemary against its harmful effect. Forty adult male albino rats were used in this study. They were classified into 4 equal groups. Group I (control), group II (control receiving rosemary), group III (mobile phone exposed group) and group IV (mobile exposed, rosemary treated group). Parotid glands were dissected out for histological and histochemical study. Moreover, measurement of oxidative stress markers; malondialdehyde (MDA) and total antioxidant capacity (TAC) was done. The results of this study revealed that rosemary has protective effect through improving the histological and histochemical picture of the parotid gland in addition of its antioxidant effect. It could be concluded from the current study, that exposure of parotid gland of rat models to electromagnetic radiation of mobile phone resulted in structural changes at the level of light and electron microscopic examination which could be explained by oxidative stress effect of mobile phone. Rosemary could play a protective role against this harmful effect through its antioxidant activity.

Conclusion

From this study, it could be concluded that exposure of rat models to non-ionizing radiation emitted from mobile phone has hazardous effects on the histology and histochemistry of their parotid glands. Administration of rosemary extract which is a natural antioxidant resulted in a significant improvement. Unfortunately these preliminary results cannot be further extrapolated to humans. Therefore, we should adjust our use for mobile.



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Also see:



AirPods: Are Apple’s New Wireless Earbuds Safe?

December 13, 2016

Apple announced today that AirPods can be ordered online and will be available in stores next week. The wireless earbuds will be available in limited quantities in more than 100 countries and territories.

Apple originally planned to ship AirPods in October and has not explained the reason for the delay. The Wall Street Journal reported that the delay was due to problems with the Bluetooth wireless technology employed by this device.

http://www.apple.com/newsroom/2016/12/apple-airpods-are-now-available.html
http://www.wsj.com/articles/apples-airpod-shipping-delay-causes-holiday-disappointment-1481299202


September 12, 2016

Apple’s new AirPods are wireless earbuds that employ Bluetooth technology to communicate with your smart phone, laptop, or smart watch. 

According to Apple, “After a simple one-tap setup, AirPods are automatically on and always connected.”

The Specific Absorption Rate (SAR) for the AirPods

The left AirPod emits Bluetooth microwave radiation in the 2.402 – 2.480 GHz frequency range to communicate with a smart phone or other wireless device. The Specific Absorption Rate (or SAR) of the AirPod is 0.466 watts per kilogram (averaged over 1 gram). (1)  For more information about the SAR see my post on the iPhone 7.

If one uses the AirPods many hours a day, the cumulative exposure to the brain from this microwave radiation could be substantial. 

According to EE Times, the left AirPod communicates with the right AirPod using a different technology, "near field magnetic induction (NFMI)."

Although there is a substantial research literature on the health risks of exposure to magnetic fields, I am not aware of any biologic research that examines NFMI. Hence, this post focuses on the risks to the brain from exposure to Bluetooth radiation. 

Is Bluetooth safe?

The wireless industry argues that devices that use Bluetooth are safe because the microwave radiation emitted by such devices is low compared to FCC guidelines. The FCC requires the SAR to be 1.6 watts per kilogram or less.

More than 220 scientists who have published research on electromagnetic radiation safety believe that current national and international guidelines for exposure to radio frequency radiation are inadequate to protect human health (see the International EMF Scientist Appeal).

I could find only two peer-reviewed studies that have examined the effects of exposure to Bluetooth radiation. The studies which employed small samples evaluated the effects of brief exposure to Bluetooth radiation on the auditory system. (2) Given the study limitations, the absence of significant effects is not surprising. These studies do not provide the basis to argue that long-term exposure to Bluetooth radiation is safe.

Low-intensity microwave radiation can open the blood-brain barrier

In 1975, Allan Frey published a paper in the Annals of the New York Academy of Sciences which reported that exposure to low intensity microwave radiation could open the blood-brain barrier in rats. Moreover, pulsed radio frequency waves (like Bluetooth) were more likely to produce this effect than continuous waves. (3)

The blood-brain barrier is a special layer of cells in the brain that prevents chemical toxins in the blood system from reaching the brain. Breaching this barrier could potentially lead to neurodevelopmental and neurodegenerative diseases and brain cancer.

More than a dozen peer-reviewed studies have replicated Frey's findingsexposure to low intensity microwave radiation can open the blood-brain barrier (see links below). (3)  

The effect of microwave radiation on the blood-brain barrier is nonlinear—it occurs with low intensity exposures but not at higher intensity exposures.

Although other published studies have failed to find the blood-brain barrier effect, these studies tended to use higher intensity exposures or employed small samples.

Recommendations

We may not be certain of the long-term risks of using Bluetooth devices, but why would anyone insert microwave-emitting devices in their ears near their brain when there are safer ways to use a cell phone?

I recommend the use of corded headsets or hands-free use of cell phones, not wireless earbuds. Moreover, one should never keep a cell phone next to your body, especially during a phone call, but also whenever the phone is powered on. For additional tips on how to reduce your exposure to wireless radiation see http://bit.ly/safewirelesstips.

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News coverage

In the past few days, numerous news stories have appeared citing industry-affiliated scientists who claim that AirPods are safe. Nonetheless, a few news reports have addressed the potential health risks from using AirPods:

·         CBS San Francisco"Apple Unveils iPhone 7 Without Headphone Jack"
·         Daily Mail“Could wireless headphones harm your health?”



Since the stories in the Daily Mail and CNN were posted on September 8, over two dozen online news stories have appeared that discuss the potential health risks from the microwave radiation emitted by AirPods.

References

(1) UL Verification Services, Inc. SAR Evaluation Report for Wireless Headset. FCC ID: BCG-A1523. Model Name: A1523. Report Number: 16U23784-S6V1. Issue Date: 8/30/2016. Fremont, CA. https://fccid.io/document.php?id=3118442


(2) Peer-reviewed studies which reported on the effects of brief exposure to Bluetooth radiation:

Mandalà M, Colletti V, Sacchetto L, Manganotti P, Ramat S, Marcocci A, Colletti L. Effect of Bluetooth headset and mobile phone electromagnetic fields on the human auditory nerve. Laryngoscope. 2014 Jan;124(1):255-9. http://www.ncbi.nlm.nih.gov/pubmed/23619813

Balachandran R, Prepageran N, Rahmat O, Zulkiflee AB, Hufaida KS. Effects of Bluetooth device electromagnetic field on hearing: pilot study. J Laryngol Otol. 2012 Apr;126(4):345-8. http://www.ncbi.nlm.nih.gov/pubmed/22310164


(3) Peer-reviewed studies which reported opening of the blood-brain barrier from exposure to low-intensity microwave radiation:

Sırav B, Seyhan N. Effects of GSM modulated radio-frequency electromagnetic radiation on permeability of blood-brain barrier in male & female rats. J Chem Neuroanat. 2016 Sep;75(Pt B):123-7  23. http://www.ncbi.nlm.nih.gov/pubmed/26723545?dopt=Abstract

Tang J, Zhang Y, Yang L, Chen Q, Tan L, Zuo S, Feng H, Chen Z, Zhu G. Exposure to 900MHz electromagnetic fields activates the mkp-1/ERK pathway and causes blood-brain barrier damage and cognitive impairment in rats. Brain Res. 2015 Jan 15. http://www.ncbi.nlm.nih.gov/pubmed/25598203?dopt=Abstract

Sirav B, Seyhan N. Effects of radiofrequency radiation exposure on blood-brain barrier permeability in male and female rats. Electromagn Biol Med. 2011 Dec;30(4):253-60. http://www.ncbi.nlm.nih.gov/pubmed/22047463

Sirav B, Seyhan N. Blood-brain barrier disruption by continuous-wave radio frequency radiation. Electromagn Biol Med. 2009;28(2):215-22. http://www.ncbi.nlm.nih.gov/pubmed/19811403?dopt=Abstract

Nittby H, Brun A, Eberhardt J, Malmgren L, Persson BR, Salford LG. Increased blood-brain barrier permeability in mammalian brain 7 days after exposure to the radiation from a GSM-900 mobile phone. Pathophysiology. 2009 Aug;16(2-3):103-12. http://www.ncbi.nlm.nih.gov/pubmed/19345073?dopt=Abstract

Söderqvist F, Carlberg M, Hansson Mild K, Hardell L. Exposure to an 890-MHz mobile phone-like signal and serum levels of S100B and transthyretin in volunteers. Toxicol Lett. 2009 Aug 25;189(1):63-6. http://www.ncbi.nlm.nih.gov/pubmed/19427372?dopt=Abstract

Eberhardt JL, Persson BR, Brun AE, Salford LG, Malmgren LO. Blood-brain barrier permeability and nerve cell damage in rat brain 14 and 28 days after exposure to microwaves from GSM mobile phones. Electromagn Biol Med. 2008;27(3):215-29. http://www.ncbi.nlm.nih.gov/pubmed/18821198?dopt=Abstract

Belyaev IY,  Koch CB, Terenius O, Roxström-Lindquist K, Malmgren LO, H Sommer W, Salford LG, Persson BR. Exposure of rat brain to 915 MHz GSM microwaves induces changes in gene expression but not double stranded DNA breaks or effects on chromatin conformation. Bioelectromagnetics. 2006 May;27(4):295-306. http://www.ncbi.nlm.nih.gov/pubmed/16511873?dopt=Abstract

Salford LG, Brun AE,  Eberhardt JL,  Malmgren L,  Persson BR. Nerve cell damage in mammalian brain after exposure to microwaves from GSM mobile phones. Environ Health Perspect. 2003 Jun;111(7):881-3; discussion A408. http://www.ncbi.nlm.nih.gov/pubmed/12782486?dopt=Abstract

Leszczynski D, Joenväärä S, Reivinen J, Kuokka R. Non-thermal activation of the hsp27/p38MAPK stress pathway by mobile phone radiation in human endothelial cells: molecular mechanism for cancer- and blood-brain barrier-related effects. Differentiation. 2002 May;70(2-3):120-9. http://www.ncbi.nlm.nih.gov/pubmed/12076339?dopt=Abstract

Schirmacher A, Winters S, Fischer S, Goeke J, Galla HJ, Kullnick U, Ringelstein EB, Stögbauer F. Electromagnetic fields (1.8 GHz) increase the permeability to sucrose of the blood-brain barrier in vitro. Bioelectromagnetics. 2000 Jul;21(5):338-45. http://www.ncbi.nlm.nih.gov/pubmed/10899769?dopt=Abstract

Fritze K, Sommer C, Schmitz B, Mies G, Hossmann KA, Kiessling M, Wiessner C. Effect of global system for mobile communication (GSM) microwave exposure on blood-brain barrier permeability in rat. Acta Neuropathol. 1997 Nov;94(5):465-70. http://www.ncbi.nlm.nih.gov/pubmed/9386779?dopt=Abstract

Salford LG, Brun A, Sturesson K, Eberhardt JL, Persson BR. Permeability of the blood-brain barrier induced by 915 MHz electromagnetic radiation, continuous wave and modulated at 8, 16, 50, and 200 Hz. Microsc Res Tech. 1994 Apr 15;27(6):535-42. http://www.ncbi.nlm.nih.gov/pubmed/8012056?dopt=Abstract

Persson BR, Salford LG, Brun A, Eberhardt JL, Malmgren L. Increased permeability of the blood-brain barrier induced by magnetic and electromagnetic fields. Ann N Y Acad Sci. 1992 Mar 31;649:356-8.
http://www.ncbi.nlm.nih.gov/pubmed/1580510?dopt=Abstract

Frey AH, Feld SR, Frey B. Neural function and behavior: Defining the relationship. Annals of the New York Academy of Sciences, 247: 433–439. 1975.